680. 



Cancer Research 



were observed. There is no evidence of malignant 

 transformation of one or several of the multiple 

 osteomas noted in the preceding section. 



Abatracto of reported otses of Osteosarcoma 



VVahlcken, 1873: A nodular growth 8 z 5.5 cm. was 

 present on the anal fin of a 3-foot pike Esox lucius. The 

 overlying skin was intact On section the tumor had the 

 appearance of bacon and was traversed by irregular 

 bony trabcculae. Microscopically the soft tissue con- 

 sisted of small, irregular cells with one or more nuclei. 

 The cells were surrounded by partially hyalinized con- 

 nective tissue. 



MuRKAV, 1908: In the subcutaneous tissue of the 

 operculum of a codfish was a hemispherical bony tumor 

 measuring 2 cms. Histologically it was composed of 

 irregular rounded masses of osseous tissue separated by 

 strands of spindle cells. Thin walled, irregularly ar- 

 ranged capillaries were numerous. 



Williams, 1929: Arising from one of the vertebrae 

 of a codfish PoUachius virens was a tumor that infiltrated 

 the adjacent muscle in all directions. Histologically it 

 consisted of bone trabeculae and spindle cells. 



Thomas, 1932 b: Immediately behind the left pec- 

 toral fin of a young codfish Gadus tnorhtta was a tumor 

 4.5 z 2 X 1.5 cm. that bulged into the j)eritoneal cavity 

 and infiltrated the adjacent trunk muscles. The neo- 

 plasm was soft, the cut surface was gray-white and 

 marked by many punctate hemorrhages. Among the 

 pleomorphic cells were plaques of osteoid tissue and 

 multinucleated giant cells. 



LIPOMA 



The fat storage depots of fishes correspond with 

 those of man, though the subcutaneous tissues are 

 not as heavily infiltrated. Nevertheless, in a catfish 

 Py^idium totae found in Lake Tota, Colombia, the.se 

 subcutaneous stores reach enormous proportions 

 (Fig. 34). Dr. L. P. Schultz, ichthyologist of the 

 National Museum. Washington, D. C., is undecided 

 whether the adiposity is characteristic of this species, 

 or whether it represents an abnormality. Histologic- 

 aHy the tissue is composed of adult fat cells, the 

 subjacent trunk musculature is not invaded, and the 

 overlying .skin is normal, without evidence of atro- 

 phy (Fig. 35). If this subcutaneous accumulation 

 of fat is pathologic for the fish, it should probably 

 be classified as a lipodystrophy rather than as a 

 true lipoma. 



Discrete lipomas have been reported 7 times in 

 the literature; each tumor in a different species of 

 fish (Table 13). All but 2 of the tumors were com- 

 posed of adult fat cells. Takahashi (199) observed 

 a lobulated lipoma, the size of a small nut, in the 

 subcutaneous tissue behind the left eye of a Japa- 

 nese samlet Plecoglossus altivelis. The tumor was 

 well encapsulated, the fat cells varied in size, and 

 the nuclei were oval or star-shaped. In 1929 Wil- 

 liams (228) reported a smooth spherical encap- 

 sulated tumor that had displaced the right eye of a 

 dragonet Callionymus lyra. Histologically, it con- 

 sisted of fat cells which the author believed had 

 undergone malignant transformation. The connec- 

 tive tissue supporting stroma was myxomatous. 



Abstracts of other reported cases of Lipoma 



Bergman, 1921: On the trunk of a lake pike Esox 

 lucius there was a subcutaneous tumor the size of a 

 man's fist. Histologically the lesion was a lipoma. 



Bergman, 1921: Beneath the skin of the pigmented 

 surface of a plaice Pleuronectes pkUessa was a tumor 

 that measured 6.5 x 3.5 x 3 cm. It was easily separated 

 from the surrounding tissue and had produced a groove 

 in the back musculature by pressure atrophy. It weighed 

 25 gm., was firm but elastic, and floated in water; its 

 parenchyma was composed of adult fat cells, 



Kazama, 1924: Within the ventral trunk musculature 

 of a flounder Paralichthys olivaceus was a tumor about 

 the size and shape of a little finger. It was encapsulated, 

 soft in consistency, and made up of fat cells. 



Williams, 1929: Protruding into the posterior por- 

 tion of the body cavity of a halibut Hippoglossus hippo- 

 glossus was a tumor that measured 27.6 x 12.5 cm. It 

 arose between the muscle bundles of the trunk. The cut 

 surface appeared oily, was pale yellow, and had the con- 

 sistency of cheese. Histologically the tumor was com- 

 posed of well differentiated fat cells, 



Thomas, 1933 d: A coalfish PoUachius carbonarius, 

 approximately 7 years old, bore a tumor, 3 x 2,5 x 2 cm., 

 on the lower border of the liver. The surface was 

 smooth and greenish, and covered by normal peritoneum. 

 On section it was soft in consistency, homogeneous and 

 without apparent fibrous trabeculae. The tumor con- 

 sisted of adult fat cells, among which were islands of 

 hematopoietic tissue. 



LEIOMYOMA 

 The four cases of smooth muscle tumors reported 



Tasu IJ: I.iroiu 



PUke PleuromseUt pUUus0 

 Pike Esox Imeku 

 FUtfiih Pwaiidkyt Mtotmu 

 HaUbttt Bippo/fossiu Uppp^tsus 

 Dmgonet CaUionymus lyra 

 Jap. samlet PUtofhssus aUMit 

 Ci ytlftth Pcttatldus (MrheHOfiui 



Site 

 Subcutaneous 

 Subcutaneous on trunk 

 Trunk muscle 

 Trunk muscle 

 Subcutaneous on head 

 Subcutaneous 

 Liver 



Author 

 Bergman, 192! 

 Bergman, 1921 

 Kazama, 1924 

 Williams, 1929 

 Williams. 1929 

 Takahashi. 1929 

 Thomas, 1933d 



