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Cancer Research 



Red tnmt 5«/m« cl^kii 

 Cod6sb PtIUddus nrtiu 

 Stint Oimtrns tpwiamus 

 Turbot Rk^mkm mtsimmt 

 Tench Tinea Hmf 

 Wnmt Latnu mistus 

 Herrinc Oupm kartngus 

 Halibut Bipp«^sus kippotlcttm* 



Tabu IS: RsAaooitYOMA 



Siu 

 Trunk muscle 

 Viscera 

 Trunk muscle 

 Trunk muscle 

 Trunk muscle 

 Trunk muscle 

 Trunk muscle 

 Trunk muscle 



Author 

 Adami, 1908 

 Fiebiger, 1909b 

 Bergman, 1921 

 Young, 1925 

 Kolmer, 1928 

 Ladreyt, 1930 

 Williams, 1931 

 Thomas, 1932a 



sixed tumor. The overlying skin was ulcerated, the sur- 

 rounding musculature infiltrated by the neoplasm. His- 

 tolagka% it consisted of fusiform and giant cells as 

 weD as myocytes. The author attempted to trace the 

 evolution of the connective tissue cells into mature 

 muscle fibers. 



WnxiAMS, 1931: In a herring Clupea harengus, 24 

 cm. in length, a tumor 3.1 cm. in diameter arose in the 

 dorsal musculature immediately anterior to the dorsal 

 fin. The overlying skin was intact. Histologically only 

 the muscle fibers in the periphery showed striations. 



Thomas, 1932 a: Along the ventral border of a hali- 

 but Hippoglossus kippoglossus was a tumor measuring 

 1.7 X l.S cm. On section it was pearly white and finely 

 ftsckuUted. There were no metastases. Histologically 

 the posterior portion of the timior consisted of undif- 

 ferentiated cells, but toward the anterior region the 

 nomul myomeric architecture was approached. A pscu- 

 docapnile was present, the result of pressure on the 

 adjacent myomeres which were infiltrated by the tumor. 

 The author discussed the embryology of fish striated 

 muscle and recognixed many of the transitional forms 

 in this ttmaor. 



HEMANGIOMA 



Hemangiomas have been reported in 1 1 species 

 (Table 16). The earliest, and to date most interest- 

 ing account of such tumors is that of Plehn (157). 

 She obaen-ed three cases in the stickleback Gasteros- 

 teus aculeatus and states that these growths occur 

 frequently in this fish. The tumors, which were 

 deep red in color, arose on the ventral surface of 

 the head, spread forward to the angle of the mouth, 

 and thence over the operculum to the level of the 

 eyes. They seemed to cause little functional em- 



barrassment. The proliferation and dilatation of the 

 vessels began in the corium and subcutaneous tis- 

 sue, then infiltrated the tissues between the gill 

 arches and hyoid bone. Solid cords of endothelial 

 cells finally penetrated to and partly replaced the 

 subjacent muscle. 



Johnstone has reported 7 of the 1 2 recorded cases 

 of vascular tumors in fishes. He identified 5 as 

 examples of angiosarcoma; however, histologic data 

 in support of this diagnosis are meager. Several of 

 the lesions reported by investigators may represent 

 a local inflammatory response rather than a true 

 neoplasm; Drew, for example, found a copepod 

 within the lesion in one of his cases. 



Abstracta of other reported cases of Hemangioma 



Murray, 1908: In the pectoral girdle of a codfish 

 Gadus morhua there was a flat, dark-colored growth 

 about 1.5 cm. in diameter. Microscopically it consisted 

 of capillaries distended with blood. 



Drew, 1912 : A reddish tumor was present in the mid- 

 line on the ventral surface of the head of a spotted ray 

 Raja maculaia at the level of the fifth gill arch. His- 

 tologically the appearance was identical with that of a 

 hemangioma of man. The body of a copepod was found 

 within the tumor. 



Drew, 1912: A nearly spherical tumor, 1 inch in 

 diameter, was found in the region of the basi-hyal bone 

 of a conger eel Conger conger. It was white and covered 

 by an irregularly thicknened and ulcerated epidermis. 

 The central portion of the tumor was necrotic. The 

 neoplasm was made up of masses of endothelial cells 

 which in some regions arranged themselves in long 

 columns that suggested capillary formation. 



Drew, 1912: A soft, red tumor was present on the 



Tasu 16: Hkmamoioiu 



Stickleback Gu t w Hwi aenUtms (3) 

 Codiiii GWw a^r Am 

 Spotted ny XV wutwltf 

 Conger od CM|ir cwfir 

 Oamord rrlfUMnMio 

 Stkltlcbock Ptu^Utms pmrngiHrn 

 ^ ff f ^^ ^ ScMiWr fCMolfw 

 roilisli ipocfat not ghron 

 Llig jr«lM mIm 

 Ploko Pltuttnttin pltttiu 

 Codhk PtOstMtu ttmu 



Site 

 Subcutaneous, head 

 Pectoral girdle 

 Subcutaneous 

 Region of basi-hyal 

 Operculum 

 Iris 



Body wall 

 Swim bladder 

 Body wall 

 Body wall 

 Trunk musculature 

 SobmucoM of rectum 



Author 

 riehn. 1906 

 Murray, 1908 

 Drew, 1912 

 Drew, 1912 

 Drew, 1912 

 Johnstone, 1915 

 Johnstone, 1924 

 Johnstone, 1925 

 Johnstone, 1925 

 Johnstone, 1925 

 Johnstone, 1926 

 Johnstone, 1926 



