Schlumberger and Lucki— Tumors in Pishes 



703 



connective tissue, but there was no evidence of 

 malignancy. Bits of the tumors ivere transplanted 

 to the subcutaneous tissue of three musk turtles and 

 three mud turtles, Kinostemum subrubrum. After 

 nine months the transplants had failed to grow, and 

 there was no evidence of recurrence at the site of 

 excbion. 



CROCODILES (CROCODILIA) 



Only two instances of neq)lasia in the CrocodUi- 

 dae have been reported. In a discussion following 

 the presentation of a paper on tumors in cold- 

 blooded animals by Pick (153) at a meeting of the 

 Berliner medizinische Gesellschaft in 1905, v. Han- 

 semann (72) said, "I wish to add that I saw a 

 lesion, very similar to that just described by Hen- 

 Heller in lizards, in a very large crocodile (the spe- 

 cies was not given) in our (Berlin) Aquarium. We 

 (grated on the animal and it turned out that we 

 were dealing with quite ordinary warts. Soon there- 

 after the animal died, whether as a result of the 

 operation or from some other cause I cannot say. 

 Nevertheless, I have the impression that the warts 

 per se had nothing to do with its death." 



A more detailed account of a neoplasm in a young 

 porose crocodile Crocodilus porosus is given by Scott 

 and Beattie (183). The first symptoms were an 

 inability to rise, and a tendency to fall on its right 

 side. A diagnosis of cerebellar tumor was made and 

 the animal was destroyed. At autopsy a tumor 

 somewhat larger than a cherry stone was found on 

 the ventral surface of the cerebellum. On micro- 

 scopic examination a few glial fibers were seen, but 

 the mass was mainly composed of small round cells 

 and a few larger, often multinucleated cells. Occa- 

 sional mitotic figures were present; the neoplasm 

 had invaded the adjacent nervous tissue. The en- 

 tire right auricle of the heart was filled with a tumor 

 that had also invaded the wall of the right ventricle 

 and the interventricular septum. Histologically, it 

 was similar to the growth found in the cerebellum. 

 In the portal spaces of the liver were numerous 

 groups of neoplastic cells; the latter were also dif- 

 fusely scattered throughout the disorganized pares- 

 chyma. The authors concluded that the tumor was 



a round cell sarcoma, prinury in the liver, with 

 metastases in the heart and cerebellum. Enmina- 

 tion of the photomicrograph reveals nochiiig to sug- 

 gest that the liver cell Itself was the neoplastic cell 

 of origin. It may be that the tumor arose in the 

 blood forming tissues (hematopoiesls b active in the 

 liver of some reptHes) and b cnmparable to lympho- 

 sarcoma of man. 



LIZARDS (SAURIA) 



Because lizards are addom bunted for food or 

 sport, it is not surprising that the six reports of 

 tumors in these animals deal with individuals kqH 

 in captivity. All but one of the lesions were neo- 

 plasms of surface qjithelium. The otoeption was a 

 case described by Bland-Sutton (12) of multiple 

 enchondromas in an Indian monitor, Varanui draco- 

 ena. The animal, which also suffered from rickets, 

 had large tumors in the fifth and seventh cervical 

 vertebrae. Two tumors were present in the distal 

 metaphysis of the right humerus, one in the left 

 humerus. Each of two metacarpal bones bore a 

 tumor near its distal end, and four were found in 

 the hyoid bone. Histologically the neoplasms were 

 composed of hyaline cartilage. It may be noted that 

 the possible etiologic relation of rickets to general- 

 ized chondromatosis in man was wiggpHfd by Vir- 

 chow in 1863. 



In a male lizard Lacerta agUis, Koch ( 1(X)) found 

 several papillomas on the frontal, parietal, and oc- 

 cipital regions of the head, as well as on the left side 

 of the thorax. The normal shape of the head was 

 altered by the tumors, which were wart-like in char- 

 acter and bluntly conical. They were firm in con- 

 sistency and on microscopic examination presented 

 the typical appearance of papillomas. 



During the discussion of a paper by Pick (153), 

 Heller (74) sUted that he had seen kerathiiaed 

 masses in the inguinal regions of several lizards 

 Lacerta muralis fiumensis. The lesions attained a 

 considerable height and hlstoiogicaliy bore a O^ 

 tain resemblance to the keratinizing condylomata 

 acumenata of man. 



Plehn (IS9) oboerved sinihur lesions in anocher 

 species of lisard, LtetrU vkUk, The j^apilfcimai 



Tasu 2S: Tohou or Liiaim (Saviu) 



Indian monitor Varanus iracotna 



LlxArd Lactrta agUis 



Lisard Lacerta muralis fiumentii (leveral) 



Lisard Laceria tiridis (teverat) 



Tegu Tupinambis Uguixin 



Tegu TupinamHs nigropuHclalus 



