1909.] 



PUBLIC DOCUMEXT — No. 31. 



185 



tured hj the Bowker Insecticide Company of Boston, and sold 

 under the trade name of Disparene. Its composition, according 

 to John P. Street of the Connecticut Experiment Station, Bulle- 

 tin No. 157, September, 1907, is as follows: — 



Before the actual feeding of the arsenate of lead was begun 

 all available literature thought likely to give some informa- 

 tion bearing on the experiment was reviewed, l)ut nothing of 

 importance other than that already mentioned was discovered to 

 indicate the probable poisonous dose, the effects of administra- 

 tion or the pathological changes j^roduced. The fact that the 

 compound is a comparatively new one (1893), and is used 

 almost exclusively as an insecticide, probably accounts for the 

 absence of any mention of it in the latest works on toxicology. 

 Even " Merck's Index " for 1907 fails to include it in its list 

 of drugs and chemicals. 



As previously mentioned, the experiment was carried on to 

 determine the effects produced by long-continued administration- 

 of small doses of the compound, such as an animal might get by 

 eating for a long time foliage, grass or hay carrying but limited 

 quantities of the arsenate of lead, and the effects of large 

 amounts given at one dose. 



Five mature cows were used in the experiment, that were 

 designated by the numerals 1 to 5. For purposes of reference 

 the details of the experiment with each animal are published in 

 full. A general summary follows the details. 



