20 ACETANILID, ANTIPYKIN, AND PHENACETIN. 



QUESTION 18. GIVE A BRIEF CLINICAL HISTORY OF EACH CASE. 



The information submitted in answer to this question is embodied 

 in the data presented in the preceding pages. 



AN INQUIRY REGARDING THE IMPORTANCE OF ILL EFFECTS OF 

 THESE AGENTS, CONDUCTED BY THE BRITISH MEDICAL ASSO- 

 CIATION. 



In 1894 a committee of the British Medical Association known as 

 the " therapeutic committee," of which Dr. D. J. Leech was chair- 

 man and Dr. William Hunter honorary secretary, conducted an in- 

 quiry with regard to " The importance of the ill effects which occa- 

 sionally attend the use of the three chief antipyretic and analgesic 

 agents, phenazone (antipyrine), acetanilide (antifebrin) and phen- 

 acetin." For the purpose of this investigation a letter of inquiry 

 was sent to medical practitioners in Great Britain requesting infor- 

 mation based on personal experience with these drugs. The replies 

 received in answer to this letter furnished much valuable information 

 and the report of the committee contained descriptions of a number 

 of cases of poisoning. The following summaries are taken from the 

 report of the committee, and contain information with regard to the 

 principal effects noted by the different observers. 



Ill effects from the administration of acctnnilirt. 



observed in Great Britain. 



n, and phenacetin, as 



[When the actual dose which occasioned the ill effect is not stated, the usual dose 

 employed by the observer is given within parentheses.] 



a Brit. Med. J., London, 1894, 1 : 85. 



