LITERATURE ON ACETANILID POISONING. 



25 



The innvMHii- use of proprietary remedies containing acetanilid 

 since tin* year IIMII i< indicated in the published reports, as follows: 



in irhirh th< /r//iY/if is reported to luivc taken a proorietani vrenaration 



1891-1907. 



|N<> cnsi reported for tho years omitted.] 



The n~e <>\' proprietary preparations containing acetanilid is not 

 mentioned in the report- -d' cases published during the eight years 

 precedini: the year I'.xi;,, luit in the reports published during 1905 

 the u>e of the-e | in-pa !';it i m> i> iixlicnteil in 55.5 per cent of cases. 

 In I'.MH; tin- \\^> ,!' ihe-e pre|);irMtinn> i- indicated in 63.1 per cent of 

 the re. 'Mule.] cases, :ind in 1007 in S 7.' per cent. It is interesting to 

 note that :i-eninp:inyiiiL r thi- rapid increase in the use of proprietary 

 aeetanilid jn-fpanil'mns during rorent years, wliich indicates a more 

 indi-eriminate n ''tanilid by the general public, there has been 



an increase in th<- t>tal number of cases of poisoning reported, in the 

 number of fatalitie^. and in the number of instances of habitual use. 

 In thi- connection a .-..rnpai i>on of the four preceding tables is of 

 interest 



ABSTRACTS OF ACETANILID CASES. 

 1886. 



BERNHEIM. I/antitY-l.rin.-. Krv. niftl. de Test. Nancy, 1886, 18: 699. 



on.- half of the patients takinu' acetanilid had cyanosis of the face and 

 rxtn-nii: grains u'iven (n a child produced chills and collapse. 



Tlm-e i-at'ients had a chill when the temperature began to rise again. 



CUIN. A., und Iln-p. I'. l>as Antifebrin, ein neues Fiebermittel. Centrbl. 

 klin. .Mrd.. I.ri|./i-. L886, 7: r,r,i. 



Cyanosis of :!.,- fa.-.- and extremities, varying in intensity, was the only 

 syinptom ol.served during the administration of acetanilid. 



1 IVoluchtunirru fiber das Antifebrin. Munch, rned. Wochenschr., 

 :::;: 851. 



Inu'.-stion of ncetanilid was followed by the appearance of a papular 

 eruption covering the entire body. 



KKIK...U. <;. Antifebrin i Acetanilin) als Antifebrile und Antisepticum. Cen- 

 trbl. klin. Med.. Leipxig. 1886, 7: 761. 



Cyanosis of the cheeks and visible mucous membranes was the only ill 

 effect observed during the administration of acetaiiilid. 



