26 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



LEPINE, R. Sur 1'action de 1'acetanilide (antifebrine). Semaine med., Paris, 

 1886, 6: 473. 



^ 



Doses of more than 7.5 grains of acetanilid, continued for several days, 

 caused cyanosis of the face and extremities. 



MOUISSET. Note sur 1'emploi de 1'acetanilide dans le traitement de la fievre 

 typhoide. Lyon med., 1886, 53: 309. 



Three out of seven cases of typhoid, treated with acetanilid in doses of 

 T.." grains, presented symptoms of cyanosis. 



RIKSE, H. Zur Wirkung des Antifebrin. Deutsche med. Wochenschr., Berlin, 



1886, 12: 835. 



Cyanosis of the face and extremities appeared in several cases, particu- 

 larly in phthisis, following the use of acetanilid. In two cases of pneu- 

 monia and one of typhoid the pulse became weak and irregular. Collapse 

 occurred after a single dose of 11.5 grains of acetanilid in a case of phthisis. 



1887. 



BAUER, F. M. The dangers of antifebrin. Therap. Gaz., Detroit, 1887 (3), 

 3: 788. 



Author had several times seen cyanosis produced in women by three or 

 four doses of 3.75 grains of acetanilid. 



BIRO, E. Az acetanilid (antifebrin) hatasarol. Gyogyaszat, Budapest, 1887, 

 27: 217. (Transl. Abs., Pest, med.-chir. Presse, Budapest, 1887, 23: 446.) 



(1) Ingestion of 7.5 grains of acetanilid was followed by a severe rigor 

 and an irregular, small pulse. (2) After taking acetanilid for eleven 

 days the patient presented the same symptoms as in case 1, and, in addition, 

 clonic convulsions of the lower extremities. 



BOROSNYOI, L. Az antifebrin mint eskorellenes szer. Orvosi hetil., Budapest, 



1887, 31: 1663. (Transl. Abs., Pest, med.-chir. Presse, Budapest, ISSK, 

 24: 103.) 



Author observed cyanosis in all cases of epilepsy treated with large doses 

 of acetanilid. 



BOULTON, P. Antifebrin. Brit. Med. J., London, 1887, 1: 761. 



On two occasions marked prostration followed the administration of 15- 

 grain doses of acetanilid to feeble patients. 



CAULDWELL, C. M. Antifebrin in the treatment of phthisis. Med. Rec., New 

 York, 1887, 31 : 426. 



Cyanosis of the lips and finger nails was noted in 2 cases out of 30 

 treated with acetanilid, in 7 to 10-grain doses. 



DEMIEVILLE, P. De I'antifebrine comme nervin. Rev. med. de la Suisse Rom., 

 Geneve, 1887, 7: 305. 



(1) In an alcoholic epileptic, 51 years of age, 7.5 grains of acetanilid 

 three or four times a day caused delirium and hallucinations. (2) Several 

 15-grain doses of acetanilid caused lachrymation and a prickling sensation 

 about the eyes. 



DOLL. Mittheilungcn nus der Praxis. Deutsche Med.-Ztg.. Berlin, 1887, 8: 817. 

 Ingestion of 25 pfennigs' worth of acetanilid, about 1.5 tablespoonfuls, 

 in two portions in close succession was followed in about three hours by 

 vomiting, syncope, and collapse. 



