28 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



HEINZELMANN, H. Zur Casuistik der Antifebrinbehandliing. Miinch. med. 

 NYofheiischr., 1887. 34: 36. 



Ingestion of 3.75 grains of acetanilid was followed in one case by dilation 

 of the pupils, in another by chilliness and profuse perspiration, and in still 

 another by weakness of the pulse. In a fourth case partial deafness and 

 headache followed the ingestion of 7.5 grains of the drug. 



HEUSLEB, E. Das Autifebrin. Allg. med. Centr.-Ztg., Berlin, 1887, 56:1074. 

 In 50 cases of typhoid and pneumonia treated with acetanilid, cyanosis 

 occurred in one instance. Average dose, 3.75 grains every six hours. 



HUBER, A. Ueber Antifebrin. Cor.-Bl. f. schweiz. Aerzte, Basel, 1887, 17:2. 

 Typhoid. Ingestion of 7.5 grains of acetanilid daily for two days was 

 followed by a papular rash especially marked on the forehead, forearms, 

 and hands. Author had also observed instances in which cyanosis and col- 

 lapse followed the ingestion of acetanilid. 



JACOB, A. Etude clinique sur 1'antifebrine ou acetanilide. Nancy, 1887. 



In 72 cases, cyanosis was observed in 12 instances following the ingestion 

 of 3.75 to 7.5 grains of acetanilid. Collapse occurred in 2 instances after 

 the ingestion of acetanilid by typhoid-fever patients ; once after the ad- 

 ministration of 7.5 grains, and again after 3.75 grains. In a case of heini- 

 plegia, a dose of half a drachm was followed by intoxication and nausea 

 lasting four hours. Three and three-fourths grains produced syncope in 

 case of a tubercular patient. 



JTTNKERMANN, F. A. Antifebrin als Febrifugum und Nervinum. Wiirzburg, 



1887. 



In erysipelas, cyanosis was observed to follow the ingestion of doses of 7.5 

 grains of acetanilid. 



MACMULLEN, J. C. On the action of acetanilide. Australas. Med. Gaz., 

 Sydney, 1886-7, 6:269. 



In at least three cases, a condition closely resembling collapse followed 

 the ingestion of acetanilid. 







MATUSOFSZKY, A. Ueber den Heilwert des Antifebrin. Orvos-termeszettud. 

 Ertesito. Kolozsvar, 1887. No. 1. (Transl. Abs., Pest, med.-chir. Presse, 

 Budapest, 1887, 23: 466.) 



(1) Cyanosis occurred in a case of phthisis after the ingestion of 0.75 

 grain of acetanilid four to five times a day. (2) Typhoid. Four doses of 

 acetanilid, 6 grains each, every half hour causes cyanosis and collapse. 



MULLER, J. Meeting of Soc. de med. de Strasbourg, Jan. 6, 1887. Gaz. med. de 

 Strasbourg, 1887, 46: 35. 



Administration of 7.5 grains of acetanilid to a patient with erysipelas 

 9 years of age caused intense cyanosis of the face. 



PAVAI-VAJNA, G. Ueber die Wirknng des Acetanilid oder Antifebrin. Centrbl. 

 gesam. Therap., Wien, 1887, 5: 481. 



(1) Man, 25, phthisis: Fifteen grains of acetanilid caused cyanosis and 

 collapse. (2) Man, 28, typhoid: Three and three-fourths grains caused 

 cyanosis. (3) Man. 27. pneumonia: Three doses of 3.75 grains at hourly 

 intervals caused profuse perspiration and cyanosis. 



