34 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



HABTGE, A. Eine Antifebrinvergiftung. St. Petersb. med. Wochenschr., 1890 

 (N. F.), 7: 69. 



Student who had been drinking heavily, took for insomnia teaspoonful 

 doses of acetanilid from an ounce box until all was taken. Symptoms re- 

 sembled those of anil in poisoning. Recovery was probably due in part to 

 the fact that the stomach contained so much liquid. 



HATTON. J. B. Some untoward effects from antifebrin. Med. Surg. Reporter, 

 Philadelphia, 1890, 62: 372. 



(1) Boy, 16, typhoid: Administration of 4 grains of acetanilid was fol- 

 lowed by cyanosis and collapse. (2) Man. 52. sciatica: Two 4-grain doses 

 of acetanilid four hours apart caused cyanosis and collapse. 



HERMANN, E. Beobachtungen fiber die Wirkungen und die Anwendungsweise 

 des Antifebrins. Deutsche Med.-Ztg., Berlin, 1890, 11 : 865, 875. 



(1) Young woman: Two doses of 15 grains of acetanilid with a half 

 hour interval were followed by cyanosis. (2) Following the ingestion of 

 2 doses of 15 grains of acetanilid the patient felt very weak and was prone 

 to fall asleep whether walking or standing. (3) Ingestion of 1 drachm of 

 acetanilid with suicidal intent was followed by great weakness, cyanosis, 

 and persistent vomiting. (4) Girl, 22. acute rheumatism: The ingestion 

 of 7.5 grains of acetanilid 3 times daily until 5 doses had been taken was 

 followed by the appearance of an urticarial eruption. 



MOLLOFF.' Discussion of paper by Khakanoff, 1889. Trans. Med. Surg. Re- 

 porter, Philadelphia, 1890, 62: 83. 



In two cases collapse followed the ingestion of one 7-grain dose of 

 acetanilid. 



MOBEHOUSE, O. E. Antifebrin rash. Montreal Med. J., 1890-91, 19: 46. 



(1) Man, 45, pneumonia: Was given, S grains of acetanilid, and four 

 hours later 8 grains more. An erythematous rash appeared upon the entire 

 body, lasting six days. (2) Girl, 19, typhoid : Six grains of acetanilid 

 caused the appearance of a rash resembling urticaria on face and chest. 

 Four hours later 5 grains more caused the rash to spread to the arms. 

 Temperature fell, accompanied by sweating. Rash disappeared after five 

 days. 



PBEININGEB. V. Otrava antifebrinem. Casopis lekaf u v ceskych, 1890, 29 : 225. 

 Abs., Sajous, 1891, 5: A-2. 



Report of a case of poisoning in which acetanilid appears to have had a 

 cumulative effect. 



SCOTT, J. T. Some peculiar results following the use of acetanilide in typhoid 

 fever; report of three cases. Cincinnati Lancet-Clinic, 1890 (n. s.), 24: 65. 



(1) Child, 3 or 4 years old, typhoid: Six grains of acetanilid 3 times a 

 day caused chills and cyanosis of the entire skin, lasting from one-half 

 hour to one and one-half hours after each dose. Subsequently 3 grains 

 caused a chill, and the administration of the drug was discontinued. 

 (2) Youth, 24, typhoid: Acetanilid, 6 grains 3 times daily, caused on 2 

 occasions severe chills and profuse sweating. Drug discontinued. (3) Ty- 

 phoid patient was given from 18 to 24 grains of acetanilid daily. Chills 

 appeared and increased in number and severity until the patient was 

 having 4 or 5 a day, Acetanilid was discontinued and the rigors ceased. 



