40 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



SLIFER, G. B. A case of acetanilid poisoning. Therap. Gaz., Detroit and Phila- 

 delphia, 1897, (3), 13: 360. 



Woman, 21: Took a little acetanilid on* the end of a spoon twice, and 

 then a teaspoonful. This was followed by vertigo, faintness, cyanosis, semi- 

 consciousness, and symptoms of collapse. There was suppression of urine 

 until noon of the following day. 



SNOW. I. M. Acetanilid poisoning in a newly born infant : Absorption from the 

 umbilicus. Med. and Surg. Reporter, Philadelphia. 1897, 76: 794. 



Application of about a drachm of acetanilid to the umbilicus of an infant 

 7 days old caused deep cyanosis and symptoms of collapse. The child lost 

 1 pound in three days. 



1898. 



BALLOU, P. V. Unusual symptoms following the administration of antifebrin. 

 Med. News, New York, 1898, 72: 791. 



Man, 45 : Ingestion of 10 grains of acetanilid was followed by the ap- 

 pearance of a general eruption, resembling that of scarlatina, with intense 

 itching, irregularity of the pulse, and a sense of impending danger. 



BROWN, P. K. A fatal case of acetanilid poisoning. Pacific Rec. Med. and 

 Surg., San Francisco, 1898-99, 13: 197. 



Man, 37: Brought to hospital thirty-six hours after he had taken 50 

 grains of acetanilid within a few hours. Was kept alive nine days. Fre- 

 quent vomiting, general hyperesthesia, deep cyanosis of lips, gums, and 

 extremities, increased reflexes, lowered blood pressure, the pulse rate 

 steadily rising until just before the end. All the symptoms of collapse. 

 Progressive destruction of red corpuscles to 1,116,000, with 30 per cent of 

 hemoglobin on day of death. Leucocytosis. Alkalinity of the blood re- 

 duced SO per cent. Hemoglobinuria began twenty-four hours after inges- 

 tion. Suppression of urine three days before death. Acute diffuse 

 nephritis. Hemorrhage from intestines. Acute progressive jaundice. 



BUEHLER, G. V. Case of acetanilid poisoning. Atlantic Med. Weekly, Prov- 

 idence, 1898, 9: 276. 



Man, 21, burn of entire back: Application of not more than 1 to 1.5 

 drachms of acetanilid was followed by cyanosis, unconsciousness, and 

 collapse. 



1899. 



GILMORE, A. W. Acetauilid habit. Philadelphia Med. J., 1899, 3: 1423. 



Woman, 58: For pain and insomnia took acetanilid regularly for twenty 

 months. At first she took 2.5 grains at a dose, but gradually increased it 

 to 10. 



WESCOTT, T. S. A case of acetanilid poisoning from external absorption in an 

 infant. Pediatrics, New York, 1899, 7: 539. 



Application of a dusting powder consisting of acetanilid in the folds 

 of the groin and thighs for chafing, caused deep cyanosis. 



1900. 



GAINES, G. W. A case of acetanilid habit. New Orleans Med. and Surg. J., 

 1900-1901, 53: 30. 



Adult negro: Had been taking acetanilid for rheumatic pain for four 

 years, and recently had been taking as much as 2 ounces each week. 



