42 ACETAXILID, ANTIPYBIN, AND PHENACETIX. 



19O3. 



HALL, J. N., and MCGBAW, H. R. Chronic cyanosis from acetanilid poisoning. 



Boston Med. and Surg. J., 1903, 149 : 626. 





 Man, 50 : Habitual use of acetauilid, 30 to 40 grains daily, for six months 



caused a loss of 20 pounds in weight, cyanosis of face and mucous mem- 

 branes, deterioration in the quality of the blood, and marked general 

 weakness. 



LUCE. T. W. The acetanilid habit Report of two cases. Amer. Med., Phila- 

 delphia, 1903, 6: 502. 



Two cases in which the habitual use of acetanilid by women caused 

 cyanosis, emaciation, general debility, and invalidisni. In the case of one of 

 the patients there were convulsive seizures. 



STENGEL, A., and WHITE, C. Y. A report of a case of chronic acetanilid poison- 

 ing, with marked alterations in the blood. Uiiiv. Peiin. Med. Bui., 1902-3, 

 15: 462. 



Woman. 25 : Habitual use of acetanilid for about seven years caused 

 cyanosis varying in degree according to the amount taken, deterioration 

 in the quality of the blood, and general debility amounting to invalidisni. 



1904. 



ELMQUIST, A. G. J. En stor Dosis Antifebrin. Hosp.-Tid. Kjobenhavn. 1904, 

 4. R., 12: 350. 



Recovery followed the ingestion of 120 grains of acetanilid taken by a 

 woman with suicidal intent. 



1005. 



MILLER, J. L. Poisoning by orangeine. J. Amer. Med. Assoc., Chicago, 1905, 

 44: 1989. 



A young woman, physically sound, had been taking orangeine powders for 

 several weeks for insomnia. Her family noticed that she was cyanotic and 

 sent for a physician, who found deep cyanosis of face, lips, and extremities. 

 She was also faint and chilly. Had taken 6 of the powders within eight 

 hours. Her family promised that she should obtain no more, but three 

 days afterwards she was found dead in bed in the morning. Coroner's 

 verdict: " Death was from the effect of an overdose of orangeine powders 

 administered by her own hand, whether accidentally or otherwise un- 

 known to the jury." 



PBOBASCO, E. B. Acetanilid poisoning. New York State J. Med., 1905, 5: 318. 

 (1) Man, 25, suffering from an attack of typhoid: Five-grain doses of 

 acetanilid every three or four hours caused cyanosis and prostration. 

 (2) Girl, 13, influenza : Acetanilid in 5-grain doses every three or four 

 hours caused cyanosis and prostration.. (3) Woman, 30: Ingestion of 

 antikarunia tablets caused cyanosis and collapse. (4) Man, 33: Ingestion 

 of 10 migraine tablets, each containing 2.5 grains of acetanilid. between 

 10 a. m. and 2 p. m., was followed by deep cyanosis and collapse. 



STENGEL, A. Chronic acetanilid poisoning; report of two additional cases. 

 J. Amer. Med. Assoc., Chicago, 1905, 45 : 243. 



(1) Man, 38: Habitual use of acetanilid in the form of cephalgin for 

 a year caused progressive loss of flesh and strength, somnolence, cyanosis, 

 increasing weakness, irritability of temper, and irregular heart action, the 

 pulse becoming rapid on slight exertion. (2) Woman, 27: Habitual use of 

 about 20 grains of acetanilid daily in the form of headache tablets caused 

 progressive loss of health and strength, with cyanosis, dyspnea, headache, 

 palpitation of the heart, increasing rapidity of the pulse and respiration 

 especially on exertion, and deterioration in the quality of the blood. 



