44 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



HEBRICK, J. B., and IRONS, E. E. Chronic acetanilid poisoning with report of 

 a case due to absorption of the drug from an ulcer of the leg. J. Amer. 

 Med. Assoc., Chicago, 1906, 46: 351. 



Woman, 50: For seven years had applied acetanilid to a large ulcer of 

 the leg. During this time she suffered from general nervousness, mental 

 depression, weakness, dyspnea, cyanosis, and palpitation. Sudden with- 

 drawal of the drug caused mania .'al excitement, proving addiction. Liver 

 and spleen enlarged. Blood showed secondary anemia. Urine dark and 

 gave test for paramidopheuol. Gradual withdrawal 'of acetanilid. Re- 

 covery. 



MORGAN, W. G. Remarkable dosage. Amer. Med., Philadelphia, 1906 (X. S.), 

 1: 245. 



The ingestion of 47.5 grains of acetanilid three times daily caused 

 cyanosis. 



PUCKETT, C. Acetanilid poisoning. Oklahoma Med. Xews-J., 1906, 14: 208. 



Man, 49: Ingestion of about a teaspoonful of acetanilid in 4 doses at 

 hourly intervals was followed by vertigo and general weakness. Slept all 

 night, but the next day he was in bed with intense cyanosis and all 

 symptoms bordering on collapse. 



QUIGLEY, D. T. Acetanilid in bromo-seltzer. J. Amer. Med. Assoc., Chicago, 

 1906, 46: 454. 



Ingestion of a heaping tablespoonful of bromo-seltzer by a man caused 

 cyanosis and symptoms of collapse. 



SUTHERLAND, E. L. Acetanilid poisoning. Med. Sentinel, Portland, Oreg., 1906, 

 14: 466. 



(1) Woman, 34: For six weeks she had suffered from vertigo, shortness 

 of breath, anorexia, nausea, and severe headaches. Her physician found 

 her unconscious, cyanosed, and in profound collapse. Inquiry showed that 

 she had been taking bromo-seltzer for two weeks in tablespoonful doses for 

 pain. (2) Woman, 32: Ingestion of perfection headeache wafers over a 

 period of three weeks caused nausea and vertigo, attacks of syncope, 

 cyanosis, loss of memory, and difficulty in concentrating the thoughts. 

 Pulse, 135, soft and intermittent; urine scant, 1.028. Convalescence lasted 

 two months. (3) Woman, 39: Habitual use of headache powders contain- 

 ing 6 grains of acetanilid powder each, caused nausea, general nervousness 

 and debility, cyanosis, and rapid intermittent pulse. (4 )_ Woman, 69: 

 Case similar to the preceding. (5) Woman, 36: Had been taking bromo- 

 seltzer in tablespoonful doses for headache for two months. Collapsed in 

 the street. Symptoms resembled those in preceding case. 



TYRRELL, J. B. Acute acetanilid poisoning. J. Amer. Med. Assoc., Chicago, 

 1906, 46: 955. 



Man, 52: Ingestion of one-half teaspoonful of acetanilid was followed 

 by intense cyanosis, syncope, and collapse. 



19O7. 



DOBSON, L. A case of poisoning by antikamnia. West London Med. J., 1907, 

 12: 226. 



Man, 54 : Took twelve 5-grain tablets of antikamnia at night. He was 

 found in bed the next morning and was at first thought to be dead. There 

 was an intense degree of cyanosis and severe symptoms of collapse. 



