LITERATURE ON ACETANILID POISONING. 45 



GLAZEBROOK, L. W. Chronic acetanilid poisoning from Harper's " brain food " 

 .1. Ainer. Med. Assoc., Chicago, 1907, 49: 1673. 



\V..ni:in. :> : Halitu:il use of acetanilid in the form of Harpers brain 

 food caused g*>mral malaise, drowsiness, fatigue on slight exertion, numb- 

 ness of lower fxtivmith's. impaired locomotion, cyanosis and puffiness of the 

 skin, tremor and rapid pulse. 



LOEWKNTHM. I 1 . Death from Koehler's headache powders. J. Amer. Med 

 ASS<H-.. Chi. -ago, 1907, 48: 813. 



Two powders caused the death in an hour and a half of James Tobias, New 

 York, who " came to his death by acetanilid poisoning administered * * * 

 in Koehler's headache powders * * * ." Each powder is said to have 

 been composed of acetanilid 76 per cent, caffein 22 per cent. 



ROOK Kit. A. M. Case of poisoning by headache powders (Shac). J. Amer. Med. 

 ' Assoc.. Chicago, 1-.M.7. 49: 1675. 



Woman, ". headache: One Steam's headache wafer was followed in half 

 an hour by dizziness and In an hour by unconsciousness, cyanosis, and pros- 

 tration. 



S\\K.I ; I.. M. .j.. ami VAN WAOMAN, D. V. Death from Taylor's antiheadache 

 .1. Aiii.-r. M.-d. Ass.*-.. Chicago, 1907, 48: 1693. 



r.\ 7 a Taylor's |n>wder containing about 4.5 grains of acet- 



anilid MI '.' M. in., nun. and 11 oYlurk. He soon became faint, the lips and 

 tonkin- hi ;itn' vrry lhn. the face yellowish, and the eyes staring and pro- 

 truding. At 1L'. l."> nuviilsloDs set in and he died at 1 o'clock, before the 

 arrival of a physician. 



from acetanilid poisoning. J. Amer. Med. Assoc., Chi- 

 cafo, 1007, W: 14 



Man. IT.*. u.-iirlit I'.m: Took three headache powders between 9 and 12 

 o'clock, each containing acetanilid I'.." -rains, caffein citrate 0.5 grain, and 

 sodium Mm rl< ma ti> .", -rains. He vomited twice and became very weak and 

 lotir. with slow pnlso. slow shallow respiration, and intense headache. 

 Tin- xanosis di'|>ened, collapse supervened, and he died in a convulsion at 

 1 p. in. Autopsy showed edema of lungs, dilatation of heart, congestion 

 (acute -l.Midy swelling) of the kidneys. Urine in bladder showed traces of 

 albumin. 



Si KM KI VM.. < <;. A case of chronic acetanilid poisoning. Pennsylvania Med. 

 .1 Ath.Mis, 1907-8, 11: 31. 



Woman, ir, : For six months had been freely dusting a large leg ulcer with 

 acetanilid. usim: a half pound weekly. For three months she suffered from 

 headache, palpitation, nausea and vomiting, dyspnea, insomnia, cyanosis, 

 and abdominal pain. Liver and spleen were enlarged, and a cardiac mur- 

 mur was present. Blood was chocolate colored and showed marked dimi- 

 nution in number of red cells to 1,860,000. Urine was almost black and 

 gave test for paramidophenol. Withdrawal of the drug was followed by 

 reco\ 



% F. B. A case of acetanilid poisoning from headache capsules with ex- 

 treme tachycardia the dominant symptom. J. Amer. Med. Assoc., Chicago, 

 1907, 49: 1027. 



Woman, 44 : Case in which the ingestion of 6 neuralgic capsules (acetan- 

 ilid and caffein) within a few hours was followed by nausea, prostration, 

 dyspnea, precordial anguish, pallor, and extreme rapidity of the pulse. 

 Rate as determined by sphygmograph was 210. 



