48 ACETANILID, ANTIPYBIN, AND PHENACETIN. 



the drug had been taken in fairly large doses for days. Whether they 

 appeared early or late, the symptoms usually came suddenly and lasted 

 only a few hours, with the exception of two or three cases, when they 

 continued for several days. In not a few instances their disappear- 

 ance was followed by desquamation. The distribution of the erup- 

 tion presented many variations. In some of the cases it appears to 

 have affected the skin of the entire body, while in others it attacked 

 only a comparatively small area for instance, the back of the hand 

 or knee. In the mild cases the eruption was a mere erythematous 

 blush, causing, however, much discomfort; but in the severe cases 

 the skin was red, swollen, and hot, and the sensation of heat and itch- 

 ing was distressing. 



Besides an eruption, the skin manifestations in poisoning by anti- 

 pyrin included edema. The swelling in most cases affected first the 

 face, especially the skin around the eyes, and the statement frequently 

 occurs in the reports that the patient's face became so swollen that 

 he was unrecognizable. The swelling in not a few instances involved 

 the skin of the entire body. Cyanosis was observed in only two or 

 three cases, and pruritus without the appearance of a rash in a very 

 few instances. 



1884. 



ALEXANDER. Zweiter Bericht tiber die Wirkungen und Nebenwirkungen des 

 Antipyrins. Breslau arztl. Zts., 1884, 6: 169. 



Four cases of typhoid fever in which the administration of antipyrin 

 was followed by the appearance of an eruption. 



BIELSCHOWSKY, E. Beitrage zur Antipyrin-Behandlung. Breslau. arztl. Zts., 

 1884, 6: 193. 



Two cases of typhoid fever in which the administration of antipyrin 

 was followed in one case by an erythematous eruption and in the other 

 by collapse. 



CAHN, A. Ueber Antipyrin und Antipyrinexanthem. Berl. klin. Wochenschr., 

 1884, 21: 569. 



Two cases, one of typhoid fever and the other of phthisis, in which the 

 ingestion of antipyrin was followed by the appearance of an erythematous 

 rash. 



DEBOVE, cited by DENUX, M. Etude sur la valeur therapeutique de 1'antipyrine. 

 Paris, 1884. 



Ingestion of antipyrin was followed by the appearance of a morbilliform 

 eruption. 



DEMME, R. Physiologische und therapeutische Beitrage zur Kenntnis des Anti- 

 pyrins. Fortschr. d. Med., Berlin, 1884. 2: 689. 



Two cases in children, one of acute rheumatism and the other of typhoid 

 fever, in which the administration of antipyrin was followed in one case 

 by the appearance of an erythematous rash, and in the other by symptoms 

 of marked depression. 



