14 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



Out of 288' practitioners who submitted an answer to this question 

 in regard to acetanilid, 219, or 76 per cent, stated that they had ob- 

 served instances of poisoning following the. use of this drug. These 

 219 observers report 614 cases of poisoning, including 17 deaths. 

 Eighty-nine, or 46.3 per cent, of the 192 physicians who submitted 

 similar information with regard to antipyrin stated that they had 

 observed toxic effects and reported 105 cases, including 5 deaths. Of 

 306 physicians who submitted data on phenacetin, 66, or 21.5 per cent, 

 reported 95 cases of poisoning, including 7 deaths. 



Of the 614 cases of poisoning which are said to have resulted from 

 the ingestion of acetanilid, 17, or 2.7 per cent, terminated fatally; of 

 the 105 cases of antipyrin poisoning, 5, or 4.7 per cent, resulted fa- 

 tally; and of the 95 cases of poisoning by phenacetin, 7, or 7.3 per 

 cent, terminated fatally. Additional information with regard to the 

 fatal cases follows : 



ACETANLLID. 



Pneumonia (child) One-half grain every two hours until 2 grains 



were taken. 



Capillary bronchitis (child) Small doses frequently repeated. 

 Capillary bronchitis (child) Small doses frequently repeated. 



Typhoid Five grains every four hours. 



Headache About 20 grains. 



Headache 'Thirty grains (?) 



Headache " Oraugeine " taken freely. 



Headache Thirteen or fourteen 5-grain doses in twelve 



hours. 



Headache Bromo-seltzer. 



Neuralgia Dose not given. 



Neuralgia of heart Five 5-grain doses in five hours. 



Burn Boroacetanilid applied freely. 



Burn (infant) Acetanilid applied freely to umbilical cord. 



Headache Excessive dose of " bromo-seltzer." 



Typhoid (child) Five grains. 



Typhoid (child) Dose not given. 



Malaria (child) One and one-half grains. 



ANTIPYRIN. 



Pneumonia Ten grains every two to three hours. Death on 



third day. 



Fever (child) ___ Twenty grains. Death in two hours. 



Acute rheumatism Autipyrin dispensed instead of -Aspirin." Quan- 

 tity not stated. Patient died suddenly. 



Headache. Ten grains, followed by 15 grains in an hour. 



Neuralgia Five grains every three to four hours. One 



drachm taken in two days. 



