

REPORTS OF PHYSICIANS. 9 



REPORTS OF PHYSICIANS WITH REGARD TO PERSONAL EXPERI- 

 ENCE IN THE USE OF ACETANILID, ANTIPYRIN, AND ACET- 

 PHENETIDIN (PHENACETIN). 



Kor the purpose of obtaining information with regard to the 

 poi>onon> rilcct> of acetanilid, antipyrin, and phenacetin from the 

 viewpoint of per-onal experience and observation, the following letter 

 of in<|iiiry was addressed ly the Department of Agriculture to medical 



prartitioniTs in tlie I'nited Mates: 



I Mill* Sl.Ml.S IKl'AltTMENT OF AGRICULTURE, 



BUREAU OF CHEMISTRY, 

 \Vnxhi n<jton, D. C., June 1, 1908. 



hi \i: Sn:: We are enlh-et ing informal ion relative to the poisonous nature of 

 acctanilid. antipyriii. and phenacet in. and in order to make the data as com- 

 plete ;is |.ov>ii,ie I ;nn sending yon a number of (Hiestions and would ask that 

 yon sii|>|ily the information requested at your earliest convenience. If there is 

 ii. -i siillieiiMit s|.a-e allow, M! t. L'ive .-ill the data yon may possess it is expected 

 that \o" \\ MI iiv,. the Maiik pages of the folder, making the statement as concise 



rible. 



The information requested is for the use of the Department in compiling a 

 Inillctiii. and iri-m-ral en-dii will ! L-i\eii f.r all data supplied. An early reply 

 will In- much appn-i-iaieil. 



.,t fully, II. W. WILEY, Chief. 



Following are the <|iieMioii- referred to in this communication, the 

 inquiries n-laiinir in each in-tanee to the three drugs acetanilid, 

 ant i|>\ i in. and phenaeetin : 



1. To what extent d<> y..u nee tin-si- drugs in your practice? 

 I'. \\ hat do-,- <|o yon onlinnrily preserihe for adults? 

 .'{. l>o yon preserihe them more or less frequent ly than formerly? Why? 

 I. What It y.mr opinion with regard to the relative safety of these three 



dn: 

 :,. Ila\e you ,,i,ser\ed instances of acute or chronic poisoning or cyanosis 



caused ly the-- drugs? How many of each? 

 f,. in what form was the drug administered ? 

 7. About what dates did the poisoning occur? 

 V Wen- the patients adults or children? 



r what ailment was the drug taken? 

 1<>. Was it ordered 1>\ a physician? 

 11. Was it used internally or externally? 



antity taken? 



I.".. <;ive brief history of cases observed by yon. omitting details. 

 14. Have you observed any cases of habitual use of any of these drugs or of any 



preparations containing them? 

 !.". In what form was the drug taken? 

 HI. Were there any ill effects? Give brief description. 



17. Were there any protracted ill effects? 



18. Give a brief clinical history of each case. 



This letter of inquiry was sent to physicians throughout the United 

 States, the ol.jeet l.eing to secure information which would represent 



