60 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



MARTIN. Mem. et bul. soc. rued. chir. Bordeaux, 1896, p. 416. 



The ingestion of antipyrin in 2.5 grain doses was followed by a general 

 pemphigoid eruption. 



SPIETSCHKA. Discussion. Verhandl. deutsch. dermat. Gesell., 1896, p. 151. 

 Wien and Leipzig. 



Woman, 34 : Took from 15 to -:2.5 grain doses of antipyrin for years. 

 At present 4.5 grains produce urticaria and edema of the face. 



WEBBER. H. W. A case of antipyrin eruption. Lancet, London, 1896, 1: 1562. 

 Woman, 53: A morbilliform eruption followed the ingestion of 10-grain 

 powders of antipyriu twice daily, for three weeks. 



1897. 



CLEMENT, V. Des accidents dus a 1'emploi de 1'antipyrine. Paris, 1897. 



Five cases in which an eruption upon the skin followed the administra- 

 tion of antipyrin, and one in which ingestion of the drug was followed by 

 marked prostration. 



DRANSART. De 1'antipyrinisme : Cas d'eczema bulleux generalise consecutif. 

 a une faible dose d'antipyrine ; deux cas de contractures musculaires. Echo 

 med. uord, Lille, 1897, 1: 144. 



(1) Man, 40: Two grains of antipyrin produced a general bullous eczema, 

 lachrymation, and the symptoms of coryza. (2) In two cases the adminis- 

 tration of 7.5 to 15 grains of antipyrin was followed by rapid contractions 

 of the muscles of the legs and arms. 



DUHOUBCAU. Accidents dus a 1'antipyrine. Med. mod., Paris, 1897, 8: 103. 



On two occasions the ingestion of antipyrin produced an erythematous 

 eruption in the case of a girl. 



EHRMANN, S. Die lokalisirten Erytheme irn Allgemeinen und die lokali- 

 sirten Antipyrinerytheme im Besondern. Wiener med. Wochenschr., 1897, 

 47:1697. 



Three cases in which antipyrin caused the development of a skin erup- 

 tion, in one of which it produced swelling of the right eyelid and itching 

 and enlargement of the papillae of the tongue. 



GOLDSCHMIDT, D. Cas d'intolerance excessive pour 1'antipyrine. Bul. gen. 

 therap. (etc.), Paris, 1897, 132: 277. 



Young woman, headache: Ingestion of a dose of migrainine was fol- 

 lowed by itching of the extremities, lips, and eyelids. On the next day 

 there was swelling of the affected parts and on the third day blisters ap- 

 peared upon the hands and feet. 



HUBER. A. Xebenwirkungen von Arzneimitteln. Cor.-Bl. f. schweiz. Aerzte, 

 1897, 27: 737. 



The ingestion of migrainine in 15-grain doses was followed by severe 

 cutaneous symptoms and ulceration with the formation of pseudo-mem- 

 branes in the mouth. 



LEROUX, C. Purpura generalise, stomatite pemphygotde hemorrhagique, 

 troubles trophiques des ongles consecutifs & 1'ingestion d'un gramme d'an- 

 tipyrine. J. din. therap. inf., Paris, 1897, p. 606. 



Woman, 32 : A general pemphygoid eruption with the formation of blis- 

 ters in the mouth and trophic disturbances of the nails followed the use of 

 antipyrin. 



