64 ACETANILID, ANTIPYKIN, AND PHENACETIN. 



the intensity of the poisoning. In many of the cases the skin, diges- 

 tive tract, or other parts of the body presented abnormal symptoms 

 in addition to those of collapse. Cyanosis, however, appeared in only 

 a very few instances. 



1884. 



HUCHARD. Nouveaux fa its relatifs a 1'action physiologique et therapeutique de 

 1'antipyrine. Bui. mem. soc. therap., Paris, 1884 (2 s.), 11:205. 



Child, 7, typhoid : Collapse followed the ingestion of 12 grains of anti- 

 pyrin. The case resembled one of carbolic-acid poisoning. 



ISRAEL, E. Om Antipyrinet. Hosp.-Tid., Kjobenhavn, 1884 (3 s.), 2: 1129. 

 Boy, 13, typhoid : Collapse followed the ingestion of antipyrin. 



MAY, F. Antipyrin, das neueste Antipyreticum. Deutsche med. Wochenschr, 

 1884, 10: 390. 



Man, 25, pneumonia : One-half drachm of antipyrin at 7 and 8 p. m., and 

 15 grains at 9 p. m. were followed by severe collapse. 



1885. 



BLORE. Death after the use of antipyrin; necropsy. Lancet, London, 1885, 1: 

 382. 



Woman, 35: At 3 p. m., her temperature being 103 and pulse 132 and 

 feeble, she was given 35 grains of antipyrin, and three hours later one- 

 half of this quantity. By 11 p. m. her temperature was normal. She 

 passed a restless night, with diarrhea and vomiting, fell into a condition 

 of collapse, and died thirty-two hours after taking the antipyrin. 



BOLDT, see Draper, W. H. Med. Rec., New York, 1885, 27 : 414. 



In 2 cases of puerperal septicemia the ingestion of 1 drachm of anti- 

 pyrin was followed by prostration and semicoma. The symptoms resem- 

 bled those of carbolic-acid poisoning. 



COSSMANN. Collaps nach Antipyrin. Prakt. Arzt, Wetzlar, 1885, 26: 106. 



Girl, 19, typhoid : Collapse followed the ingestion of 1 drachm of anti- 

 pyrin in 2 doses, with a two-hour interval. 



FAVRE, C. De 1'antipyrine dans la fivre hectique des tuberculeux. Lyon, 



1885. 



Pulmonary tuberculosis. A dose of 22.5 grains of antipyrin was followed 

 by nausea, chills, and coldness of the lower extremities. Later, a drachm 

 administered within five hours produced a tendency to collapse. 



GOTZE. Einige Bernerkungen iiber die Wirkung des Antipyrin. Berl. klin. 

 Wochenschr., 1885, 22: 145. 



(1) Five hours after taking 1.25 drachms of antipyrin in 3 doses the 

 temperature fell to 96.6, with cyanosis and symptoms of collapse. A 

 similar result followed the ingestion of 1 drachm, and later 0.75 of a 

 drachm. (2) Boy, 14 : The ingestion of 37.5 grains of antipyrin in 3 doses 

 was followed by symptoms of collapse and a fall in the temperature of 9. 



HUMBERT-MOLLIERE. Discussion of paper by Rollet. Lyon med. 1885, 49: 472. 

 Collapse followed the ingestion of antipyrin in the case of an old tuber- 

 culous woman. 



