70 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



1885. 



BARIE, E. Note sur la valeur comparative de, 1'antipyrine et du sulfate de 

 quinine, dans le traitement de la fievre typhoide. France med., Paris, 1885, 

 2: 1727. 



Two cases of typhoid fever in which the administration of antipyrin was 

 followed by mild symptoms of coPapse. 



FEDELI, C. Di alcuni fenomeni susseguiti all' uso dell'antipirina in un caso di 

 febbre etica. Raccoglitore Med., Forli, 1885 (s. 4), 24: 414. 



Following the ingestion of antipyriu the patient's temperature rose to 

 106.6, accompanied by chills and syncope. 



1886. 



JOHNSON, R. Clinical observations on the action of antipyrin and thallin. 

 Lancet, London, 1886, 2: 388. 



(1) Phthisis: Marked prostration followed the ingestion of antipyrin in 

 three doses of 10, 20> and 20 grains, respectively. (2) Three 15-grain 

 doses at intervals of one hour caused similar symptoms in a boy, with 

 the addition of a scarlatiniform eruption. 



1887. 



GUTTMANN, P. Zwei Beobachtungen iiber Nebenwirkungen des Antipyrin. 

 Therap. Monatsh. Berlin, 1887, 1: 214. 



Report of two cases of antipyrin poisoning, one characterized by cyanosis 

 and marked prostration, and the other by an itching eruption. 



SEIFERT, O. Ueber Antipyrin als Nervinum. Centrbl. klin. Med., Leipzig, 

 1887, 8: 649. 



(1) Ingestion of 15 grains of antipyrin was followed by pains in the 

 extremities, dizziness, and headache. (2) A dose of 15 grains of antipyrin 

 given at 7 p. m. was followed by a severe buzzing in the ears, which 

 prevented sleep for several hours. 



WEIR, A. H. Dangers of antipyrin. Med. News, Philadelphia, 1887, 51 : 166. 



A dose of 7 grains of antipyrin was followed in five minutes by roaring 

 in the ears, lachrymation, a burning sensation about the neck and face, 

 precordial distress, and dyspnea. On another occasion 7 grains, and later, 

 3.5 grains, produced a similar train of symptoms. 



1888. 

 MAYOR, A. Abs., Brit. Med. J., London, 1888, 2 : 787. 



Author states that he had repeatedly observed instances in which serious 

 toxic symptoms followed the ingestion of antipyrin in doses as small as 

 7.5 grains. 



MONOD, L. Accidents determines par 1'absorption d'une faible dose d'antipyrine. 

 Tribune rneU, Paris, 1888, 20: 113. 



A dose of 7.5 grains of antipyrin was followed by symptoms of coryza, 

 dyspnea, aphonia, swelling of the eyelids, lachrymation, and general weak- 

 ness, without fever or eruption. 



1880. 



BERGER, H. Ueber einen Fall von Antipyrinintoxikation. Therap. Monatsh., 

 Berlin, 1889, 3: 185. 



Ingestion of 15 grains of antipyrin by a patient 22 years of age was fol- 

 lowed by dyspnea, palpitation, swelling of the face, profuse salivation, 

 increased secretion of tears, and perspiration, and a feeling of paralysis 



whifli Iflstfrl for 



