LITERATURE ON ANTIPYRIN POISONING. 73 



SYMPTOMS. 



Iii then- CMS the nervous -ymptoms appear to have been very 

 prominent. The symptoms varied widely in the different cases. For 

 example, there was i'n one case what appeared to be temporary 

 paralysis, and in several, excessive restlessness or convulsions. In 

 others there were disturbances of sensation, like numbness, tingling, 

 formication, and sensation of prickling. In still others there were 

 disturbaner- of liearinir or speech, great mental excitement, excessive 

 sneezing, vertigo, delirium, or coma. In one or two instances the 

 -ymptom- re-rmUrd those of hysteria. 



less. 



<;i./i ii. Lrs a.-.-idmt* dr rantipyrinr. <;.-i/.. hebd. med., Paris, 1888, 25: 183. 

 of 1"' grains .if Miitipyriii was followed by itching of the gums, 

 snrv/ing. ami :i tickling sensation in the larynx, causing cough 

 and hoarseness. 'I'll is was followed by symptoms of coryza. On another 

 ision ."-.7", msrd siiniliir syinptoins, but inikler in degree. 



l'..i<onini: by ;i t. n grain dose of antipyrine. Med. Reg., Philadel- 



phia. isss. :{; 



Woman. LT>. lirad:i-hr: 1 ngestion of 10 grains of autipyrin was followed 

 by '(Stressing nervous syinptiims, including pain in the head, excessive 



snrr/inu'. swirling of tb.- .-\.'s :md la<-hrymation, and maniacal excitement. 



Koi-.i:. .!. T. Idiosyncrasy with ivganl to antipyrin. lancet, London, 1888, 2: 



Woman, headache: A dose of 15 grains of antipyrin was followed by 

 nansra. sinv/in::. symptoms of coryza, dyspnea, and aphonia. 



\\ . \. [dkMgrncnn with regard to antipyrin: A warning. Brit. Med. 



.1 . London, isvs." 1 : -j|::. 



Thr in-. -lion of r, -rains of antipyriu by a young woman was followed 

 by tin- apiK-arancv of an nrtirarial eiuption and disagreeable nervous symp- 

 toms. in.-ludmi: r\,rsM\, s.iM-xinu'. dyspnea, profuse sweating, coppery 

 taste and smHl. rinu'ing in the -ars, etc. 



1SSO. 



BATH N. K. !>.. and UOKIINHAM. T. .1. A contribution to our knowledge of the 

 ,,!,, a. -lion of antipyrin. Brit. Med. J., London, 1889, 1: 1^4. 



(1) In ra. h of .". . -ases of iwisoning by antipyrin there was great restless- 



ness, anxi.-ty. ami giddiness, and a sensation of prickling in the feet. (2) 



r 1 taking -ir, -rains of antipyriu daily for chorea became, on the third 



morning. di"\ v >\. di/xy. and finally delirious, with slow, labored breathing. 



1S93. 



COIIN. M. Antipyrinintoxiration. Therap. Monatsh., Berlin, 1892, 6: 624. 



\ doM Of T.r. u-rains of antipyrin was followed by dizziness, incoherent 

 h, and vomiting. 



1895. 



Li \\ i\. ;. I!*rl. klin. Wwhenschr., 1895, 32: 727. 



H> Antipyrin taken for headache caused convulsions and delirium. 

 (2) Thr in.-rstion of autipyriu was followed by severe dyspnea. 



