74 ACETANILTD, ANTIPYRIN, AND PHENACETIN. 



DANCOUBT, C. Un cas d'intoxication profonde par 1'usage immodere de 1'anti- 

 pyrine. ** Nord. med., Lille, 1904, 10: 89. 



Patient, 55: Habitual use of 0.5 drachm -of antipyrin daily had a detri- 

 mental effect upon the nervous system, causing abolition of the reflexes 

 and slight paralysis. 



'MOUTH SYMPTOMS. 



In these cases the toxic symptoms were exhibited chiefly by the 

 mucous membrane of the mouth. There was, in most instances, a 

 burning, prickling sensation, which was followed by swelling and the 

 development of small blisters upon the tongue, inside of the cheeks or 

 gums, with subsequent ulceration. In most- cases the ulcers healed 

 kindly. In one of the cases a number of abscesses formed in the 

 mouth. 



1880. 



BOURNS, D. C. G. Unusual effects of antipyrin. Brit. Med. J., London, 1889, 

 2: 818. 



A dose of 20 grains of antipyrin was followed by cyanosis of the lips, 

 swelling of the tongue, and the development of small ulcers within the 

 mouth. 



1890. 



SALINGER, J. .L. A case of antipyrine poisoning, with the formation of mem- 

 branes in the mouth, and symptoms of Laryngismus stridulus. Amer. J. 

 Med. Sci., Philadelphia, 1890 (u. s.), 99: 489. 



Woman, 53 : A dose of 5 grains of antipyrin was followed by dyspnea, an 

 urticarial eruption, swelling of the lips and tongue, coma, and symptoms of 

 collapse. On the third day a white membrane formed upon the tongue, 

 lips, and pharynx, and soon after 13 abscesses the size of a chestnut or 

 smaller developed in the mouth. On two subsequent occasions the iugestiou 

 of 5 grains of the drug was followed by similar symptoms, 



1891. 



VEIEL. Ein seltener Fall von Blaseuausschlag in Folge von Antipyrin. Arch. 

 Dermat. Syph., Wien, 1891, 23: 33. 



Man, 33, headache: Ingestiou of 15 grains of antipyrin was followed by 

 itching of the palms and soles, swelling of the lips, and the formation of 

 blisters in the mouth. Similar symptoms appeared whenever the patient 

 took antipyrin. 



1893. 



GOURIN, E. Des accidents dus a 1'antipyrine. Paris, 1893, p. 59. 



Ingestion of 15 grains of antipyrin was followed by swelling and ulcera- 

 tion within the mouth. 



1894. 



BRASCH, M. Zum Capitel der Antipyrinexantheme. Therap, Monatsh., Berlin, 

 1894, 8: 565. 



Ingestion of 30 grains of antipyrin was on four occasions followed by 

 swelling of the lip with the formation of blisters and the appearance of 

 white plaques on the tongue. 



