76 ACETANILID, AXTTPYRIX, AND PHENACETIX. 



1OO6. 



LEVES. E. Zur- Kenntniss der Migraninvergiftuiuz. Berl. klin. Wochenschr^ 

 1906, 4S: 766. 



Ingestion of 15 grains of migrainine was followed by swelling and ulcera- 

 tion of the macous membranes of the mouth and profuse salivation. 



EYE SY1PT< 



Under this heading are included the cases in which the acuitv 

 vision was diminished or the sight temporarily lost, and also the cases 

 characterized by the symptoms of coryza, with swelling of the lids. 

 lachrymation. and, in some instances, photophobia. The symptoms 

 in most cases appeared promptly, sometimes, it seemed, almost a.- 

 soon as the drug reached the stomach. 



Horx. F. C. A case of antipyrin amaurosis induced by one hundred and thirty 

 grains taken in forty-eight hoars. Arch. Ophth^ New York, 1906, 35: 160. 



Man, 33 : Had taken antipyretics for pain for three years. One hundred 

 and thirty grains of antipyrin within forty-eight hours caused bis sight 

 to become dun, and within two days it was lost; completely. It returned 

 slowly and in two months he was practically well again. 



I*OUYE, M. Antipyrin keratitis. OphthalmoL, Milwaukee, 1905-6, 2: Blfi 



Woman, 48: Ingestion of 25 grains of antipyrin in 2 doses was followed 

 by the development of 41 superficial infiltrations upon the cornea, 25 upon 

 the right and 16 upon the left The author also reviews a case reported 

 by Mizno, in which ulcers developed upon the cornea as a result of the 

 ingestion of antipyrin. 



GExrro-URiXARr STMPTOMS. 



Under this head are grouped the cases in which the toxic effects of 

 antipyrin were exhibited chiefly in some part of the genito-urmary 

 tract. The symptoms presented were principally albuminuria, sup- 

 pression or incontinence of urine, or symptoms of urethro-cystitis. 



^ i. 

 MULLER. F. Beobachtungen fiber Antipyrin. CentrbL klin. Med_ Leipzig, 1884, 



Drowsiness and involuntary micturition appeared in two cases after the 

 ingestion of antipyrin. 



1QS5. 



HAVES, EL C. Discussion of Mason's paper. (1885.) p. 538. 



Infant: Ingestion of at least four 10-grain doses of antipyrin at inter- 

 vals of half an hour caused vomiting and complete suppression of urine 

 for over twenty-four hours. 



* Xihon^Gankwa-Gakkwai-Zasshi, 1904, roL 11. 



