LITERATURE ON PHENACETIN POISONING. 

 1S95. 



79 



CON/AM/, v CAMPO, J. Intoxicacion por la autipirina 

 Her. <le ined. y cirug. pract., Madrid, 1895, 36: 209. 



dosis terapentica. 



Case in which the ix>isonous effects of antipyrin may have been brought 

 about by a cumulative action due to imperfect elimination. 



1897. 



PAFILLOH, 0. i: Note sur MM CM rare de dermatoneurose consecutive a 

 riiitf'stion <rantipyriiie. Kcho nid. nord, Lille, 1897, 1: 97. 



<Jirl. !'.: Habitual use of antipyrin. Gradually increased the amount 

 until she was taking fr.,m 1 to 1.5 drachms daily. The symptoms resem- 

 bled those of uk-er of the stomach. 



ACETPHENETIDIN < PHENACETIN). 

 INTRODUCTORY RESIT MK. 



Following U a list of the recorded cases of poisoning by acetphe- 

 netidin ( phenacetin) from issT to the close of the year 1907, with 

 a brief abstract of each case. During this period 70 or more cases 

 were reported by 11 observen, A- already stated, it is practically 

 impo ible t< determine the number of the cases with accuracy, owing 

 to the imleiinite character of -ome of the reports. Of the total num- 

 ber of cases, 3, or 4.2 per cent, are report nl to have terminated fatally. 

 Thi> number. 7n. U notably le than the reported number of cases of 

 poi-onini: by either acetanilid or antipyrin, and this fact tends to sub- 

 Mantiate tlie cominon belief that of the three drugs acetphenetidin is, 

 un.ler ordinar \ ciivu instances, the least liable to produce ill effects. 



The number of cases ..f poi-oning reported in each year since the 

 introduction of acetphenetidin a^ a remedial agent, together with the 

 number of obenven, i- -liown in the following table: 



of <i<-tti,litn'ti'lin i i>tn'n<ir,tin ) 



annually, 1887-1907. 



cases reported for y-ars omitted.] 



1 1 will be seen that 23, or 32.8 per cent, of all the cases were reported 

 during the year following the advent of acetphenetidin as a medicine 

 in 1887, and that 40, or 57.1 per cent, were reported during the years 

 1888, 1889, and 1890. The large proportion of cases reported during 

 this period was undoubtedly due in part, as in case of acetanilid and 

 antipyrin. to the fact that at this time the depressing effect of acet- 



