80 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



phenetidin was not fully appreciated, and it was administered more 

 or less freely in asthenic as well as sthenic affections. This method of 

 administration resulted in the production* of ill effects in not a few 

 cases. After the year 1890 the number of cases of poisoning reported 

 annually was, upon the average, only two or three cases, and the 

 number appears to have decreased rather than increased as the years 

 passed. 



The ill effect which appears to occupy the place of greatest im- 

 portance in the recorded cases is general systemic depression. This 

 symptom appears to have been present in 27, or 38.5 per cent, of the 

 cases. In 12 cases, or 17.1 per cent, it amounted to actual collapse, 

 and in 15, or 21.4 per cent, it was present in a milder form. Cyanosis 

 was reported in 34.3 per cent of the cases, and the comparatively fre- 

 quent occurrence of this symptom indicates the close pharmacological 

 relationship which exists between acetphenetidin and acetanilid. 

 Skin affections of various kinds were noted in 30 per cent of the cases, 

 dyspnea in 14.3 per cent, and disturbances of the functions of the kid- 

 neys in 10 per cent. 



ABSTRACTS OF ACETPHENETEDIN (PHENACETIN CASES. 



KOBLER. G. Das Acetphenetidin als Antipyretic-inn. Wien. inerl. Wochensehr., 

 1887, 37: 868. 



In a phthisical patient two doses of phenacetin of 4.5 grains each within 

 two hours caused the patient's temperature to fall rapidly to 95 in the 

 rectum, with profuse perspiration and a feeling of chilliness. 



CABSLAW, J. H. Phenacetine as an antipyretic. Glasgow Med. J., 1888, 30: 64. 

 A single dose of 5 grains of phenacetin caused collapse in three out of 

 five tubercular patients to whom the drug was administered. 



CATTANI. G. La fenacetina. Gazz. ined. ital. lomb., Milano, 1888, 48 (9 s. 

 vol. 1) : 455. 



The author had twice observed hematuria and nephritis following the 

 ingestion of phenacetin. He had also observed an acne-like eruption. 



HOPPE, H. Ueber die Wirkung des Phenacetin. Therap. Mouatsh., Berlin, l^x 

 2: 160. 



(1) Anemic girl took 19 grains of phenacetin, and after four hours a 

 second powder. This was followed by dizziness, shivering, yawning, chilli- 

 ness. blueness of the nails, and some nausea. (2) Woman. 44: The in- 

 gestion of 15 grains of phenacetiu for headache was followed by chills and 

 dizziness. (3) Thirty grains of the drug taken by a healthy student were 

 followed by persistent yawning, nausea, insomnia, general weakness, feeble 

 pulse, and inability to stand. The symptoms lasted for three hours. (4) 

 AYonian. 20: The ingestion of 15 grains of phenacetin for headache was 

 followed in fifteen minutes by chilliness, coldness of the extremities, severe 

 palpitation, and a sensation of intense fear. The symptoms passed off after 

 six hours. 



