LITERATURE ON PHENACETIN POISONING. 81 



\. JVKS, H. II. I'eber die neueren Aii t \ \ lyret ica und ihre Wlrkung am Krauken- 

 hette. Therap. Monatsh., Berliii, 1888, 2: 189. 



Author h:nl observed that the administration of 1.5 to 3 grains of phe- 

 nacetin to children in a number of ruses produced profuse sweating, severe 

 ami even symptoms of collapse. 



Li M.MANN. rnamrenelime. bedrohliche Nebenwirknngen des Phenacetin 

 Therap. Monatsh. I'.erlin. iss.s. 2: :;t7. 



Woman. 34. S.M.H after taking 15 grains of phenacetin she felt dizzy, 

 cold, and nauseated. Her headache became worse, and after three hours 

 she took another phenacetin powder. This was followed by an aggravation 

 of Hie <yniptoins; the nausea and sensation of chilliness increased, the 

 hands, lips, and checks were deep blue, and there was cold perspiration and 



riea. 



M.MiM.icr. 1'. I eber I'lienacetin voni klinischen und physiologischen Stand- 

 punkte. I>eiit>che in.-d. Woehenschr.. Leipzig, 1888, 14: 1051. 



A ner\ou> \\..m .in. after taking l.;..". Drains of pheuacetin for headache, 

 developed a well -marked urticaria on the face and chest. 



M\-n B. < oiitrihution a lY-tude d<- proprietes therapeutiques de la phenacetine. 

 Hull. a. -ad. i hHg., I'.ruxelles. isss ,4 s. ) . 2: 815. 



1 Hirl. 1'.'. typlioid : Was -ixen 7.." -rains of phenacetin at 3 and at 8 



oVliN-l; a. in. About an hour after the second dose she complained of th'or- 



u. a sensation of intense heat, marked prostration, and deep 



<sed off on the following day. On the preceding 



day the patient had taken :U grains of phenacetin without ill effect. (2) 



iirl. I-", typhoid: Fi\e hours after taking two doses of phenacetin of 3.75 



.ich the patient's temperature rose rapidly with a severe chill. 



There was also slight cyanosis of the extremities. (.'{) Woman, 24: The 



Mion of ihree doses ot phenacetin of 7..", grains each was followed after 



four hour- l>\ a WWB ''hill and cyanosis of the lips and skin around the 



in two instances the ingestion of phenacetin by tubercular 



patients produced ill ; ineipally chills and cyanosis. In one case 



the doxe \\a- 1.', grains, an-1 in the other ' grains. 



Mi MM:. I . I ebet Acetphenetidin. Therap. Moiiatsh., Berlin, 1888, 2: 355. 



Author observed cyanosis and methemoglobinuria in two patients who 

 were taking from L." to _ drachms of phenacetin daily. 



in MM. [Jeter das phenacetin. Herl. klin. Wochenschr., 1888, 25: 459, 



The ingestion of IT, -rains of phenacetin was followed on several succes- 

 la\s |,\ a feeling of thoracic oppression and slight dyspnea. 



V.M , Kin Fall von Phenacetinexanthem. Therap. Monatsh., Berlin, 



I 



Two hours after taking a dose of 15 grains of phenacetin the patient felt 

 a sensation of heat and by the next day the entire skin was covered with 

 red spot*. The eruption was especially marked upon the extremities. It 

 disappeared after twenty-four hours. 



18S9. 



3 }:. <>ni s. k. kontrar verkan af febermedel. TJpsala Liikaref 

 rr.rh.. lss.s-s!>. 24: LM;:;. 



Author observed in a patient a rise of temperature after the administra- 

 tion of phenacetin. 



8231U Bull. ll'O 09 - 6 



