82 ACETANILID, ANTIPYRIN, AND PHENACETIN. 



HIRSCHFELDER, L. Beitrag zur Wirkung des Phenacetins. Deutsches Arch, 

 klin. Med., Leipzig, 1888-89, 44: 434. 



The ingestiou of phenacetiu was followed by the appearance of red con- 

 fluent niacules, accompanied by a sensation of burning and prickling. The 

 symptoms disappeared on the following day. 



HOLLOPETER. W. C. Phenacetine poisoning. Med. News, Philadelphia, 1889, 

 55: 335. 



Woman, 30 : Took three doses of phenacetin of 7.5 grains each within 

 six hours. She passed into a state of collapse, with severe precordial pain, 

 great dyspnea, lividity of the skin, and great restlessness. The cyanosis 

 persisted for three days. 



HORVATH. A. A'datok a pheuacetin hetasuhoz. Orvosi hetil.. Budapest. 1889, 

 33: 474. (Abs. Pest, med.-chir. Presse. Budapest, 1889, 25: 1134.) 



Report of two cases in which the use of pheuacetin was followed by an 

 eruption upon the skin. 



OEFFINGER. Eine eigenthiimliche Nebenwirkung des Phenacetin. Aerztl. Mitth. 

 Baden, Karlsruhe, 1889, 43: 110. 



The ingestion of 30 grains of phenacetin in two doses with an interval 

 of three hours caused edema of the lower eyelids. A few days later 45 

 grains in three doses caused edema of the face and fingers. 



TBIPOLD, F. Ueber die therapeutische Wirkung des Phenacetin und Thallin. 

 Wien. kliu. Wochenschr., 1889, 2 : 151, 178. 



Author states that in his experience doses of 4.5 grains of phenacetiu 

 had produced deep cyanosis of the face and hands and profuse perspiration 

 in children suffering from tuberculosis. In a case of pneumonia a dose of 

 4.5 grains caused severe collapse, with cyanosis. Even 3 grains caused 

 chills, collapse, and cyanosis in two cases in children. 



189O. 



COLLISCHONN. Phenacetin als Antirheumaticum. Deutsche med. Wocheuschr., 

 Leipzig, 1890, 16: 97. 



The ingestion of phenacetin was followed by repeated vomiting, so that 

 the administration of the drug had to be stopped. 



RIFAT. Traitement du rhumatisme aigu et biennorrhagique par la phenacetine & 

 haute dose. Bui. gen. therap. (etc.), Paris, 1890, 118: 410. 



(1 and 2) In two cases pneumonia and tuberculosis, respectively, doses 

 of 4.5 grains of phenacetin caused profuse perspiration, a tendency to 

 syncope, and great restlessness. (3) In a case of typhoid fever, cyanosis 

 followed the administration of large doses of phenacetin. (4) Woman, 65, 

 articular rheumatism, with arteriosclerosis: The ingestion of 75 grains of 

 phenacetin daily was followed on the fourth day by the appearance of 

 uremic symptoms. There were vomiting, severe dyspnea, fear, and almost 

 complete suppression of the urine. 



UBALDI, A. Sull' aumento dell'acido solforico accoppiato nelle urine in seguito 

 alia somministrazioue di fenacetina. Azione tossica della fenacetina. 

 Riforma med., Napoli. 1890, 6 (1) : 752. 



1891. 



DEMME. Ueber die Wirkung und Dosirung der hauptsachlisten neueren Anti- 

 pyretica, mit Beziehung auf das Kindesalter. Therap. Monatsh., Berlin, 

 1891, 5: 160. 



Author had observed an eruption resembling that of measles, and cya- 

 nosis of the cheeks and mucous membranes in children after the use of 

 phenacetin. 



