LITERATURE ON PHENACETIN POISONING. 83 



HAKK. II. A. Fever : Its pathology and treatment by antipyretics. 1891 Phila- 

 delphia and London, p. 122. 



The author mentions two cases in which the ingestion of 5-grain doses of 

 phenae.-tin was followed by the appearance upon the skin of large wheals, 

 like those observed in urticaria. 



1SO3. 



FIKNAMU/. I>K IMAKKA. A. M. I'll c.nso de envenenamiento con fenacetina' 

 rurarion. <;a<-. ni.'-d. ratal., P.areHona. 1S92, 15: 229. 



TIN. ,111. \V. K. iwuiiar \asmmitor disturbance after the administration of 

 phiMiacetine. Me<l. i;>. \.'\\- York. lx2, 42: 341. 



The author had observed three cases with almost identical symptoms. In 

 each of them phenaeetin alone produced no disturbance, but if champagne 

 were taken in addition, even after the lapse of some hours, the patient's 

 face became flushed, the eyes suffused, and the conjunctiva bright red. 

 While siK>ts appeared irregularly over the neck, face, and chest and vertigo 

 was present. Whisky. I. randy, and claret alone did not produce these 

 effects. 



1S03. 



IMOWAY. II. Does phenacetin possess convulsivant properties? Med. News, 

 Philadelphia. lv>:;. r,:t : _ 



Report "' tWO .-as in whirh r. grains of phenacetin produced typical 



hyttero-ei'ilepiie com ulsions in WIIMMI. 



1QO4-. 



!Iu:oii>. .1. I'npleasant f plienaeetin. Practitioner, London, 1894, 



:>:*: 444. 



The patient, a woman, took from 5 to 8 doses of phenacetin of 10 grains 

 i-a.-h within ir hours. Almost immediately she complained of 



palpitation of the heart: her face, except the bridge of the nose, became 

 s -arlet : her pulse became very rapid, and she suffered from headache and 

 shortness of breath. 



KNOWLES, F. E. Symptoms of poisoning from a probable overdose of phenace- 

 tine. M,-,l. K.-. '.. .\Vu York, 1894, 46: 564. 



Patient took headache i>owders of unknown composition, and then 10 

 grains of phena.-etin. There followed a chill, prostration with marked 

 cardiac depression, cyanosis, particularly of the extremities, and cold per- 

 spiration. The pulse was 40 and scarcely perceptible at the wrist. Recov- 

 ery after three hours. 



I>AVIS. .7. s. A report of three cases of addiction to coal-tar derivatives. 

 Ainer. Mtl. and Surg. Bui., 1804, 7: 1490. 



Woman: Had been addicted to the phenacetin habit for about seven 

 months, daily quantity being between 15 and 20 grains. Addiction was 

 discovered by her husband when her supply of the drug gave out and the 

 local pharmacist also ran out of a supply temporarily. Violent convulsive 

 and hysteri.-al sei/nres followed and continued until phenacetin was secured 

 for her. Pulse. 17<>. and very weak. Respiration, 30, spasmodic. Pupils 

 widely dilated ; pallor, cold perspiration. She had more than a dozen con- 

 vulsions and vomited freely. Before beginning the habit she was "a 

 healthy, buxom country girl." Examination made after the attack above 

 descril>tl showed some anemia, complexion bad, circulation weak, pulse 

 124. restless and troubled sleep, impaired digestion, occasional vertigo. 



