84 ACETAXILID. AXTIPYRIX, AND PHEXACETTX. 



CERNA. D. Pbenacetin as a toxic agent. Tr. Texas Med. Assoc., Galveston, 



Infant. 5 days old, was given seven 2-g-rain phenacetin powders within 

 two days. It became fretful, weak, and cyanosed. On the next day the 

 conjunctiva was jaundiced, the skin cyanosed. and the child very restless. 

 On the day following there was extreme cyanosis, and bloody urine was 

 passed in large quantity. 



KRONIG, G. Phenacetin-Vergiftung init todtlichein Ausgang. Berl. klin. 

 Wochenschr., 1S95, 32: 998. 



Boy. 17: After taking 15-graiu doses of phenacetin for headache for 

 three weeks, a' dose caused vomiting, followed on the next day by prostra- 

 tion. cyanosis of the face, weak pulse, and diarrhea. Jaundice followed, 

 and the cyanosis spread to the extremities. The urine consisted of almost 

 pure blood. Death occurred, after two days, from methemoglobinemia. 



LACKIE. J. L. Note on phenacetin as causing dyspnoea and orthopnoea. Med. 

 Press and Circ., London, 1895, 60: 208. 



(1) Dyspnea and great restlessness followed the ingestion of phenacetiu 

 every two hours in 15-grain doses. (2) The ingestion of 20 grains of 

 pheuacetin every two hours caused marked dyspnea, which lasted for one 

 hour. 



WEST, R. M. Two cases of phenacetin rash. Lancet, London. 1895, 1 : 91. 



(1) Ingestion of two 5-grain tabloids of phenacetin by a man 28 years 

 of age was followed in three hours by the appearance of a scarlatiniform 

 rash upon the face, chest, and arms. It disappeared in two hours. (2) A 

 young woman took phenacetin in doses of from 5 to 15 grains for neuralgia. 

 On each occasion an urticarial rash appeared, chiefly upon the face and 

 neck, after a lapse of one or two hours. 



1896. 



BETTS, W. A. A case of phenacetin idiosyncrasy. Brit. Med. J., London, 1896, 

 1 : 146. 



Patient took 8 grains of phenacetin every three hours for headache. 

 After the third dose he felt very ill, and his face became pale. This was 

 followed by shivering, dyspnea, cold perspiration, and the development of 

 wheals on the back of the hands and on the right shoulder. The face was 

 of a mahogany color and swollen. Dread of death. Recovery. 



1899. 



GULEKE, H. Taubheit in Folge von Phenacetinmissbrauch. Zts. prakt. Aerzte, 

 Frankfurt, 1899, 8: 765. 



Male, 48: Ingestion of 10.5 grains of phenacetin every two hours until 

 10 doses had been taken caused cyanosis and complete deafness. 



1901. 



KIBBE, M. E. Ecchymotic spots and pruritus due to phenacetin. Occidental 

 Med. Times, San Francisco, 1901, 15: 371. 



Woman. 50: Ingestion of six 5-grain powders of phenacetin during the 

 evening and morning caused itching of skin over abdomen and limbs. On 

 the fourth day large areas of ecchymosis appeared on the inner surface of 

 each thigh, and smaller ones on the abdomen and extensor surfaces. 



