LITERATURE OX PHENACETIN POISONING. 85 



1003. 



WHITK. A. T. A cue of acute dysentery, in which death occurred from acute 

 cardiac dilatation probably due to chronic phenacetin poisoning. J. Trop. 



invest ion of about 3,000 grains of phenacetin in 5-grain doses within 

 dajl f..r fever was accompanied by great depression and a rapid 



dilation of the heart followed by death. The result may fairly be attrib- 



uf'-d to tin- inordinate use of the drug. 



19O4. 



I-\' W "f poisoning by phenacetin and antikauinia. Brit. 



Med. J.. London. 1904, 1: .Mr,. 



Tin- invest ion ,,f 7." -rains each of phenaretin and nntikamnia was fol- 

 lowed by vomit ini: .-Hid malaise. The face became pinched and pale, and the 

 .\piv>si.ni anxious The eyes were small and the lips and fingers purple. 

 prostration with eold perspiration. 



I."i:i. V. A-piri; : .- \ .henacet inm.'i -e/esek. (Aspirin and phenacetin poison- 

 inir. Huda p.-.ti onr. ujsag.. 1004, 2: 803. 



Hn:>. IN M h. \I. Kin Fall von ehroniseher I'henacetin-Vergiftung. Deutsche 

 m.-d. Wochenschr . Leipzig. 1905, 81: 66. 



The inx'estion ,,f phenacetin for headache was followed by the appearance 

 of an eruption of jeteehial s| M >ts ujMm the legs, followed in the course of 

 .1 \\eeU l>\ MM t-iat ion. The uk-ers healed rapidly when the drug was dis- 

 continued. niid appeared airain after another dose of L'r> grains. 



Mi i UK i . .1. Contribution A lY-tude de la toxicite de la phenacetine. Ann soc. 

 .! n nd.. 1905, 85: !!>!. 



The invest ion ..f ir, -rains of phenac-tin every two hours for twenty-four 

 hour*- \\:i^ followed l'\ L'i'eat weakness and then symptoms of collapse, 

 with tendency to syn.-o|... vertiiro. dyspnea, cyanosis of the extremities, 

 pni-ordial pain, nausea, and rapid and feeble pulse. The skin was of a 

 \ello\\ ish -ra\ color, and on the next day there appeared a macular 

 e-yMieiiia. K.-covery after five days. 



1907. 



I.. Katal jMiisoning ly |>henaeetin in headache tablets. Monthly 

 Bulletin of th- Stair Hoard of Health of Massachusetts, January, 1908. 



On Friday. I Member i: 1 ,. l'.M)7. at !i.2o p. in., a girl of 16.5 years, in good 

 -en. -i-a! h.-Mlih. but havinir a headache and feeling that she had taken cold, 

 _' li.-adache tablets and went to bed. Later, her mother heard her 

 ami went to her. There was nothing at this time to cause alarm, 

 but a little before 11 o'clock the girl's lips and face began to become blue, 

 and in eonsequence a physician was sent for. He responded at once, and 

 found the girl with great weakness of the heart and edema of the lungs. 

 Before he could administer any remedy she was dead. 



The box with tbre remaining tablets was sent to the office of the state 

 boMi-d of health for examination. The tablets were found to contain 

 phenacetin. The box was labeled " Danbury's Headache Tablets." 



o 



