134 THE PROTEIN SUBSTANCES. 



according to PICK, on the contrary yields considerable t}rrosine and indol, 

 only little leucine but no glycocoll, and contains only about 25 per cent 

 basic nitrogen. FRIEDMANN, HART, and LEVENE have obtained very 

 similar results in regard to the quantity of basic nitrogen in the two pro- 

 teoses, although LEVENE as well as ABLER l did not find the same results 

 as PICK in regard to the amounts of monamino-acids in the two pro- 

 teoses. These divergent results may be explained by the fact that they 

 were not working with pure substances, but rather with mixtures. Accord- 

 ing to HASLAM 2 the so-called protoproteoses is a mixture of two pro- 

 teoses which he designates a and /? protoproteose which have different 

 precipitation properties with alcohol and with one-half saturation with 

 ammonium sulphate. 



According to PICK the heteroproteose is also more resistant toward 

 trypsin digestion than the protoproteose, a behavior which coincides 

 with KUHNE'S view of a resistant atomic complex, an antigroup, in the 

 protein bodies. KUHNE and CniTTENDEN 3 regularly obtained on the 

 tryptic digestion of heteroproteose a separation of so-called antialbumid, 

 a body which is attacked with great difficulty in tryptic digestion, but 

 which separates as a jelly-like mass and which is richer in carbon (57.5- 

 58.09 per cent), but poorer in nitrogen (12.61-13.94 per cent), than the 

 original protein. The occurrence of such resistant complexes in diges- 

 tion has also been repeatedly observed. 



This antialbumid has recently attracted further attention, because 

 as first found by D ANILE WSKY and other investigators, OKUNEW, SAW- 

 JALOW, LAWROW, and SALASKIN and KURAJEFF, have further shown, 

 that solutions of rennin, gastric juice, pancreatic juice, and papain cause 

 a coagulum in not too dilute proteose solutions. These coagula, called 

 plasteines (coagulum by rennin) by SAWJALOW, and coaguloses (coagu- 

 lum by papain) by KuRAJEFF, 4 are similar in many respects to anti- 

 albumid, having a higher content of carbon (57-60 per cent) and nitro- 

 gen (13-14.6 per cent). In other cases the quantity of carbon as well 

 as nitrogen is lower (LAWROW). 



We cannot for the present make any positive statement as to the 

 importance and mode of formation of the coaguloses or plasteins. It 



1 Hart, Zeitschr. f. physiol. Chem., 33; Pick, ibid., 28; Friedmann, ibid., 29; Levene, 

 Journ. of Biol. Chem., 1; R. Adler, Die Heteroalbumose und Protalbumose des Fibrins. 

 Dissert. Leipzig, 1907. 



2 Journ. of Physiol., 32 and 36. 



3 Kiihne and Chittenden, Zeitschr. f . Biologic, 19, 20. 



4 The works of Danilewsky and Okunew are cited and reviewed in the following: 

 Sawjalow, Pfliiger's Arch., 85, and Centralbl. f. Physiol., 16; and Zeitschr. f. physiol. 

 Chem., 54; Lawrow and Salaskin, Zeitschr. f. physiol. Chem., 36; Lawrow, ibid., 51, 

 53 and 56; Kurajeff, Hofmeister's Beitrage, 1 and 2; see also Sacharow, Biochem. 

 Centralbl., 1, 233; Levene and v. Slyke, Biochem. Zeitschr., 13. 



