186 CLASSIFICATION OF THE MICRO-ORGANISMS. 



Renal 

 deposits. 



No physio- 

 logical excre- 

 tion through 

 the urine. 



Occurrence in 

 man. 



intravenous injections usually kill the animals after from 

 two to nine days. On post-mortem examination the 

 most characteristic alterations are found in the kidneys, 

 which present the appearance of a septic embolic 

 nephritis ; whitish yellow masses from the size of pin 

 points up to that of peas are present, and at times large 

 wedges which infiltrate the kidney like pyramids. Many 

 capillaries are completely blocked with thrombi consist- 

 ing of cocci, as are also the smaller arteries in the cortex 

 as well as a few straight tubules. Further, purulent 

 metastases often occur in joints, in the muscles, and, 

 where fractures have been recently made, in the medulla 

 of the injured bones ; frequently, however, the latter 

 situation escapes, although recent fractures are present. 

 Small quantities of the fungus are at times without 

 effect, even when injected into the veins ; nevertheless 

 in these cases also deposits appear to form in the kidneys, 

 but remain limited and heal. 



The deposits in the kidneys do not arise as the result 

 of the excretion of the staphylococcus by the kidneys, 

 nor does the localisation occur here in connection with 

 any protective excretion; on the contrary, it has been 

 demonstrated by the experiments of Wysokowitsch* 

 that not a single coccus appears in the urine during 

 the first six hours after the injection of large quantities 

 of staphylococcus, and that when cocci can be cultivated 

 from the urine deposits are always demonstrable in the 

 kidneys. The cocci introduced into the blood are 

 deposited in various organs, especially in the spleen, in 

 the medulla of bone, &c., and they either soon die or 

 remain for a long time capable of development. 



Staphylococcus occurs very frequently in man ; it is the 

 most common pyogenic organism. The experiments of 

 Rosenbach and Passet, repeated recently with great care, 

 have shown that materials mechanically and chemically 

 irritating (turpentine and mercury) can only excite sup- 

 puration in extremely exceptional cases, when micro- 

 organisms are not present at the same time. In almost 

 all the cases of suppuration which come under observa- 



* Gottinger hygien. Tnstitut. 



