MICROCOCCI PATHOGENIC IN MAN. 193 



a number (17 and more) of successive cultivations on new Artificial 

 nutrient jelly, and in these cases typical erysipelas has 3th e a X 

 resulted. The experiments were carried out on patients 

 who were suffering from malignant tumours, which 

 could not he operated on (lupus, carcinoma, sarcoma), 

 and this was done hecause former experience has shown 

 that these tumours often improve in a remarkable 

 manner, or entirely disappear after recovery from an 

 accidental attack of erysipelas. Such an "erysipele 

 salutaire " has several times during the last few years been 

 induced by inoculation of pure cultivations, and often 

 with good therapeutical results. The incubation period 

 in the cases observed by Fehleisen extended from 15 to 

 61 hours ; the disease always commenced with an initial 

 rigor, elevation of temperature, and disturbance of the 

 general health. Individuals who had suffered from an 

 attack of erysipelas a short time (up to some months) 

 before the inoculation proved to be immune. 



Streptococcus pyogenes malignus. 



Cultivated by the author from necrotic masses in a 

 leucaemic spleen. Not distinguishable microscopically 

 from the streptococci previously described, the cultiva- 

 tions are also very similar in appearance; the colonies 

 on gelatine plates and in puncture cultivations appear 

 somewhat smaller and grow more slowly, so that they do 

 not begin to be visible till after about 48 hours. The 

 stroke cultivations resemble most closely those of 

 Strept. pyog. Experiments on animals yield results 

 which differ in an important manner from those attained 

 by the other streptococci ; mice inoculated subcu- 

 taneously with small quantities of the cultivation die 

 almost without exception after 3 5 days; a large 

 collection of pus is found at the place of inoculation, a 

 moderate number of diplococci and short chains of cocci 

 in the blood and especially in the spleen, at times also 

 deposits of micrococci in the internal organs. The 

 disease may be transmitted to other mice by small 

 pieces of the tissue, or by the blood, if not in too small 



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