264 



BACILLI PATHOGENIC IN MAN. 



tubercular 

 affections. 



The bacilli are probably first introduced into the 

 diseased tissue by wandering cells which take up and 

 transport the bacilli, which are not themselves capable 

 of independent movement it is possible that this trans- 

 porting wandering cell becomes then transformed into 

 an epithelioid cell and afterwards into a giant cell. In 

 many infective experiments wandering cells containing 

 tubercle bacilli can be directly demonstrated in the blood 

 and tissues. 

 Distribution Koch examined in man 19 cases of miliary tubereu- 



of the bacilli -, . ., , . , .. , .... 



in the various 1( !1S > m no " e ot which the bacilli were missing from the 



tubercular nodules : 

 29 cases of phthisis 

 of the lungs (8 com- 

 plicated with intes- 

 tinal tuberculosis) ; 

 here also the bacilli 

 were constantly 

 found, and apart 

 from the sputum 

 they were most 

 numerous in fresh 

 cheesy infiltrations 

 and in the interior 

 of cavities where the 

 walls were rapidly 

 breaking down. In 

 tuberculous ulcers 







Fig. 76s. Giant cell containing a 

 tubercle bacillus ; section from lupus 

 of the skin X 700. 



of the tongue, in tuberculosis of the pelvis of the kidney, 

 of the uterus, of the testicle, &c., the bacilli were con- 

 stantly found ; likewise in 21 cases of tuberculous glands. 

 Farther, they were present in 13 cases of tuberculosis 

 of the joints and 10 cases of tuberculous affections of 

 bones ; in 4 cases of lupus, where the bacilli were only 

 found in giant cells, and only one organism in each ; in 

 7 cases of bovine tuberculosis ; finally, in various animals 

 inoculated with tubercular material (273 guinea-pigs, 

 105 rabbits, 44 field mice, 28 white mice, 19 rats, 13 cats, 

 as well as dogs, marmots, fowls, pigeons, &c.). Further, 

 sputa and organs in a very large number of other non- 



