MALARIA. 2C7 



however, as yet doubtful whether the granules and 

 bodies observed are to' be looked on as parasitic forms, 

 or only as secondary products of the breaking up of 

 blood corpuscles arising under the influence of micro- 

 organisms as yet unknown. 



This last assumption, which is nevertheless equally 

 justified, would open up the prospect that .we must 

 search for the true infective agents of malaria with other 

 technical means than have as yet been tried ; and it is 

 probably advantageous to remember that these agents 

 may not necessarily belong to the class of fission fungi, 

 but to some other class of micro-organisms. 



In the case of yellow fever Babes demonstrated in two 

 cases short rods, similar to the typhoid bacilli, with 

 large spores, usually at one end, and present in the 

 mucous membrane of the small intestine. As regards 

 the presence of cocci in this disease, see page 203. 



In the case of whooping cough, Letzerich (Yirchow's 

 Archiv, 1874) looks on the infective agents as cocci, 

 and Burger (Berl. klin. Woch., 1883) as short rods 

 often constricted in the middle, and present in the 

 sputum of the patient ; nevertheless there is no sufficient 

 support for either of these views. 



In some cases of lichen ruber, Lassar observed, on 

 staining with fuchsine, the tissue at the same time 

 being stained brown, distinct and extremely fine bacilli, 

 which are aggregated in thick masses, and can only be 

 recognised as individual rods under very high powers. 

 They lie chiefly in the lymphatic channels of the aifected 

 parts in the form of tube-like masses. 



In the case of xerosis conjunctives, Leber, Kuschbert 

 and Neisser, and Schleich found micro-organisms. 

 Leber describes them as short rods, often resembling 

 cocci, which grow readily on nutrient gelatine, and 

 when inoculated in large numbers on the conjunctiva of 

 rabbits (the eyes of the animals being kept closed for 

 forty-eight hours by means of superficial sutures) led to 



