306 



BACILLI PATHOGENIC IN ANIMALS. 



Spore forma- have, however, failed to observe any movement. In 

 cultivations in meat infusion which have stood for three 

 days at the temperature of the room, or for 24 hours at 

 40 C., we can observe the formation 

 of small spheres which probably repre- 

 sent spores, although, on account of 

 the minute size of the object, no accurate 

 observations have as yet been made as 

 to the formation and sprouting of these 

 bodies. In old cultivations the ordinary 

 involution forms, such as club-shaped 

 swellings of the threads, drum-stick 

 forms, &c., appear. 



These cultivations, after being carried 

 for a series of generations through 

 gelatine or meat in- 

 fusion kill with great 

 certainty the ordinary 

 house mice in the 

 course of two to four 

 days, and on examin- 

 ation numerous fine 

 bacilli are found in the 



Inoculation on 

 unimals. 



Fig. 86A. Cultivation of the bacilli of 

 swine erysipelas in gelatine. 

 , puncture cultivation. 

 b, colony on a plate X 80. 



Pasteur's 

 protective 

 inoculation . 



blood and in the capil- 

 laries of all the organs. Pigeons are very susceptible, 

 and die within three or four days. Rabbits are less sus- 

 ceptible ; after inoculation on the ear of a rabbit an 

 crysipelatous inflammation occurs in the first instance, 

 just as after inoculation with the bacilli of mouse sep- 

 ticaemia. As a rule general infection follows and causes 

 death in five to six days, nevertheless not uncommonly 

 complete recovery takes place. Sheep, and perhaps also 

 young cattle, are susceptible; on the other hand guincu- 

 pigs and fowls are completely immune. The cultiva- 

 tions have also been repeatedly inoculated with success 

 on swine belonging to susceptible races, and at a sus- 

 ceptible age. 



Swine erysipelas has quite recently excited special 

 interest because Pasteur has recommended a special 

 mode of protective inoculation which has been experi- 



