BACILLUS SEPTICUS AGRIGENUS. 321 



death occurred much more quickly than in the case of 

 the first species, often even after 18 hours, at the latest 

 after 40 hours. Kabbits were completely immune. 

 Cultivation experiments showed at most a multiplication Cultivation 

 of the bacteria in the blood inoculated on the first sub- SSS^ enta 

 stratum ; further attempts at inoculation were always unsuccessful, 

 unsuccessful. 



The following bacteria isolated from saliva by other 

 authors are either identical with one or other of these 

 species, or it may be different from them, but this can- 

 not be decided on account of the absence of sufficient 

 -characteristic distinctive points. 



Pasteur obtained a microbe from the saliva of a child Pasteur's 

 which had died of hydrophobia. Kaynaud and Lanne- hydrophobia, 

 longue had discovered that the inoculation of such saliva 

 on rabbits caused the illness and death of the animals ; 

 Pasteur confirmed these experiments, and cultivated 

 a micro-organism from the blood of the rabbits in 

 veal broth, this organism being rod-shaped and some- 

 what constricted in the middle in the form of a figure 

 of " 8 " ; the organism was only 1 p. in diameter, and 

 was surrounded by a gelatinous substance like an 

 aureole. In the cultivations these rods were said to be- 

 come converted into chains of cocci. Fowls and guinea- 

 pigs were not susceptible to the action of the microbe. 

 Although at first Pasteur supposed that he had ob- 

 tained the infective agent of hydrophobia, he succeeded in 

 setting up the same disease, and found the same organ- 

 isms in rabbits inoculated with the saliva of healthy 

 human beings. In like manner Vulpian was able to set other similar 

 up, by inoculation of normal saliva on rabbits, a disease 

 which ended fatally in two days, and which could be 

 transmitted from animal to animal by small quantities 

 of blood. Fraenkel also obtained a similar result by the 

 inoculation of his own saliva. (See Literature, p. 37.) 

 Klein has set up infective diseases in rabbits and 

 mice by the sputum of patients suffering from pneu- 

 monia, and he has described the infective agents of 

 these diseases as belonging to various species of micro- 



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