BACILLUS NEAPOLITANUS. 837 



sloughs on Peyer's patches were found. Where the 



dose was smaller the course of the disease was more 



protracted, and in these cases the ulcerations in the 



intestine were more extensive and deeper. If the culti- 



vations were injected into the peritoneal cavity death 



generally occurred in 8 to 10 hours. Cats were less 



susceptible, relatively larger quantities of the culti- 



vation being required in order to cause infection ; and 



still larger quantities were necessary in the case of 



dogs and rabbits. Of the dogs infected only one died 



on the third day, while the others recovered after 



being ill for several days. A monkey died after 



42 hours, and showed similar alterations in the intes- 



tine ; Peyer's patches were of a dark brownish-red 



colour, and distinctly swollen. The guinea-pigs as 



a rule passed pulpy motions during life ; the cats 



suffered from vomiting and diarrhoea ; the monkeys had 



also vomiting, with repeated watery stools. From the 



results of the experiments on animals, and of the proof 



furnished by cultivation that the bacilli were present in 



the blood and in all the organs of nine patients who had 



died of cholera, and that they were also present in the 



blood of patients in the last stage of the disease, 



Emmerich has come to the conclusion that these organ- 



isms are the exciting agents of cholera. Nevertheless, 



the results of the experiments on animals did not differ 



in any important particular from those obtained by the 



numerous forms of bacteria mentioned above and the 



method employed by Emmerich to demonstrate the 



presence of bacilli in the organs was by no means free 



from error. In more recent investigations made on Occurrence of 



eight cholera bodies in Palermo, Emmerich and Buchner 



were unable to confirm the occurrence of these organ- of patients 



suffering from 



isms in the blood and in the internal organs, but found cholera. 

 them chiefly or only in the intestines and lungs. 



It is evident that the presence of these organisms in 

 the intestines of cholera patients can only be of sig- 

 nificance if it is shown that the same bacillus is not 

 present in the normal intestine, nor in intestines in 

 which any other pathological process is going on. Such 



22 



