BACILLUS PARVUS OVATUS. 339 



into the anterior chamber of the eye, with a piece of the 

 growth, or with a portion of an affected organ, they die 

 on an average after about eight days ; at the seat of inocu- 

 lation necrotic caseous processes are found, and in the 

 lungs there are deposits surrounded by hsemorrhagic 

 pneumonia, or accompanied by necrosis of the whole of 

 the affected portion of the lung ; there are also deposits 

 in the heart. Where these deposits have reached the 

 surface of the organs they cause exudation on the serous 

 membranes. The alterations are chiefly limited to the 

 lungs and heart, and it is only seldom that nodules are 

 also found in the abdominal organs. In all these 

 morbid products the same thin bacilli were constantly 

 present. White mice die after inoculation in six days ; On mice. 

 at the seat of inoculation there are greenish-yellow 

 masses infiltrating the muscular tissue of the back over 

 a large area, extending deeply into the muscles of the 

 thigh, and ultimately reaching the peritoneum. In 

 sections of the tissues which are altered in this way, 

 long bundles of these bacilli are seen. 



Bacillus parvus ovatus (Loeffler). 



In a pig which had died of a disease resembling Bacilli of 

 erysipelas, Loeffler * found on microscopical examination erysipelas of 

 of the oedematous skin, and also of the liver and kidneys, 8wine - 

 large numbers of small ovoid bacteria, sometimes re- 

 calling in form the bacilli of rabbit septicaemia, more 

 especially in those forms which are undergoing division, Microscopical 

 but distinguished from these organisms by the fact that characters - 

 the latter are almost twice as large. In sections the 

 organisms are best demonstrated by staining with 

 alkaline methylene blue, and subsequent treatment 

 with 1 per cent, of acetic acid ; in the skin they are 

 arranged in rows following the bundles of the con- 

 nective tissue. They grow readily in various nutrient Cultivations. 

 media, in rabbit broth and blood serum; in nutrient 

 jelly they develop somewhat better at the point of 

 entrance of the puncture than along the needle track, 



* Arleiten a. d.Kaiserl Ges. AmL, vol. i., 1885, p. 51. 



