SPIRILLUM CHOLERA ASIATICS. 421 



their differentiation from each other. This was the 

 case, for example, with the spirilla observed by Finkler 

 and Prior in dejecta, by Deneke in cheese, and by Lewis 

 and Miller in the deposit on teeth. (See below.) 



Even Koch's opponents have had to admit that their efforts 

 to find Koch's comma bacilli elsewhere than in the dejecta of 

 cholera patients have completely failed. Klein was compelled 

 by Watson Cheyne's objections to make such an admission; 

 and Buchiier says in his most recent publication, " Koch's 

 assertion that the vibrio found by him in the cholera process is 

 exclusively limited to that process has as yet been unshaken." * 

 In peculiar contrast to this statement of Buchner's is one Admission of 

 made by his fellow-worker Emmerich in the same number of ** ?v imi ^u' ti ?3i 

 the Arcliiv fur Hygiene, p. 358 : " The markedly alkaline exu- to cholera. 

 dation, rich in oxygen, washes out the intestine and removes 

 the numerous micro-organisms which live there, while, on the 

 other hand, it forms an admirable nutrient medium for Koch's 

 vibrios, which also occur in limited numbers in the normal 

 intestine, and which multiply enormously in cholera, and in 

 many cases awake the suspicion that they are causally con- 

 nected with the alterations." In support of this assertion, Unfounded 

 which is of such extreme importance with regard to the Emmerich' 3 '' 

 etiology of cholera, Emmerich has brought forward no proof, 

 either from those portions of his experiments as yet published, 

 or from those of any other investigator, and hence the state- 

 ment is simply incorrect. 



Hence we can no longer doubt that Koch's comma Deductions 

 bacilli occur constantly and exclusively in Asiatic stamj^ofThe 

 cholera ; further, that they are found in the intestine in occurrence of 

 numbers which are larger according as the cholera runs 

 a purer and more typical course, and they are present t 

 in the intestine in largest numbers at those parts where cholera 

 the cholera process has set up the most marked altera- pl 

 tions, namely, in the lower portion of the small intes- 

 tine. This coincidence cannot be an accidental one ; 

 on the contrary, the two phenomena, the cholera 

 process on the one hand, and the appearance of the 

 comma bacilli on the other, must stand to each other 

 in the relation of cause and effect. In explana- Necessity for 

 tion of this constant concurrence we have only two J^^^* 1 

 possibilities. Either the cholera process is the cause connection 

 of the presence of the large numbers of the comma 



Arch.f. Hygiene, vol. iii., 1885, p. 438. and cholera - 



