24 THE ARRANGEMENT OF THE 



If at the ordinary temperature of the room we watch a pale 

 corpuscle, we recognize light offshoots slowly changing their 

 shapes, which protrude from the periphery of the corpuscle, while 

 the groups of the granules in the protoplasm are also changing 

 their shape and location. The latter changes consist in an alter- 

 nating accumulation and separation of the granules, or their 

 transformation into a delicate reticulum. 



Almost every coarsely granular body shows under a high 

 amplification the following, in the course of from half to one 

 hour : Each single granule at first represents a globular, yellow- 

 ish, very shining body, which is separated from its neighboring 

 granules by a light, narrow rim, and this rim is traversed by 

 rather indistinct delicate spokes, connecting each granule with 

 all its neighbors. Each granule continually changes its location, 

 the more noticeably the greater the distances between the single 

 granules. At the same time, hyaline flaps begin to protrude from 

 the periphery of the granular blood-corpuscle. Soon each gran- 

 ule becomes flattened, cup-shaped, and all of them are now seen 

 distinctly connected by gray spokes. Meanwhile the circumfer- 

 ence of the whole body has enlarged. Next, in every single 

 granule there appear one central or two excentric vacuoles, which 

 by enlarging and coalescing hollow out the granule so as to make 

 it look like a single or double shell, or ring. Two or more hollow 

 granules suddenly coalesce and are transformed into a delicate 

 reticulum, to such an extent that in place of the former coarse 

 granules a pale, finely granular protoplasm has made its appear- 

 ance. Inside of it a hollow body becomes visible, inclosed by a 

 relatively thick and scolloped shell, and containing several coarse 

 granules. Such a body, in accordance with our usual terminology, 

 must be called a nucleus. 



The pale protoplasmic bodies come from coarsely granular 

 ones, continue for a time to change their shape j the nucleus and 

 its granules (the nucleoli), on the contrary, from the moment 

 they have appeared, do not change. 



Upon adding a one-half per cent, solution of chloride of gold 

 to a fresh specimen of blood, the liquid was transformed into a 

 finely granular coagulurn. The pale protoplasmic bodies had be- 

 come globular, and the coarsely granular transformed into many- 

 shaped masses, having in their interior a delicate reticulum 

 surrounded by a continuous layer. In both kinds the nuclei 

 remained coarsely granular and coarsely reticular. After one 

 hour, the solution of gold being drained off, and the specimen 



