68 STRUCTURE OF COLORED BLOOD-CORPUSCLES. 



give to the inexperienced observer the impression of internal 

 granules; but proper focusing corrects this impression, and 

 shows the knobbed surface. (Fig. 22, I). 



FIG. 23. COALESCENCE OF Two OR MORE CORPUSCLES, GIVING EISE TO 

 CHAINS AND IRREGULARLY SHAPED COMPOUND BODIES, WITH THE NET- 

 WORK STRUCTURE VISIBLE. 



In addition to the protean changes in shape initiated by in- 

 dentation and protrusion, there are still others occasionally met 

 with, due to combination or coalescence of two or more cor- 

 puscles. In the course of twenty-four 

 hours or more though this occurs 

 in by far the smaller number of prep- 

 arations of blood examined two or 

 more adjacent colored blood-cor- 

 puscles may, with a larger or smaller 

 portion of their periphery, unite 

 and form compound bodies, some- 

 times chains or other strange shapes. 

 (Fig. 23.) 



Almost immediately on being ready 

 for examination, a very few colored 

 blood-corpuscles show a light central 

 vacuole. In the course of the examina- 

 tion, a number of vacuoles, either of 

 different sizes or all of the same size, 

 may appear in a corpuscle. Usually, 

 a vacuole is round or roundish, but it 



to be close together and in the third may assume various irregular fomiS 



figure, the separating walls of ap- J 



parently five vacuoles have broken SOme of which may perhaps have 



resulted from a union of several, and 

 the breaking down of the separating 

 walls. (See Fig. 24. The three lower 

 figures show appearance of vacuoled corpuscles seen on edge.) 

 Vacuoles sometimes persist, and sometimes, after a longer or 



FIG. 



24. VACUOLED COR- 

 PUSCLES. 



In the upper line are seen three 

 corpuscles, each with a different 

 sized central vacuole ; in the middle 

 line, the first figure shows three vacu- 

 oles in one corpuscle; these vacuoles 

 are represented in the second figure 



down, and one irregularly shaped 

 larger vacuole is seen. The lower 

 line shows the appearance of vacu- 

 oled corpuscles seen on edge. 



