72 STRUCTURE OF COLORED BLOOD-CORPUSCLES. 



especially in the corpuscles not much paled; in one instance, 

 a pale ring was also seen with a large pedunculated protrusion 

 (Fig. 26). During two hours, changes of scalloping and of knobs 

 took place faster than is usual with blood mixed with a 40 per 

 cent, or 50 per cent, saturated solution, but they could not be fol- 

 lowed so distinctly. Extreme paling rapidly proceeded, and much 

 detritus filled the field, with only very few compact globules. 



With a 90 per cent, saturated solution, the process of scallop- 

 ing was completed in twenty minutes ; and in thirty minutes a 

 net-work was visible in a few roundish corpuscles, surrounded 

 by masses of granular detritus. In addition, a large number of 

 " ghosts " could be seen. Here and there a u ghost " would show 

 a faint net- work. 



With a saturated solution added undiluted, the net- work was 

 after one hour visible in some corpuscles, but most of them were 

 destroyed ; of a few left intact, some looked homogeneous, and 

 some vacuoled. The field was full of faint, double-contoured 

 rings and a large quantity of granular detritus. 



The net- work structure of colored blood-corpuscles is visible 

 also in anatomical preparations which have been kept for a length 

 of time in Mutter's fluid. 



In some of my examinations, especially the earlier, I used the 

 heated stage ; but as the phenomena described were seen at the 

 ordinary temperature of a well-warmed room, I deem it best not 

 to say anything here of variations of temperature. 



In this communication I omit the mention, also, of the 

 remarkably varying amount of fibrine threads seen in different 

 preparations of blood ; nor do I enter at length into the question 

 of " detritus formation," or whatever else one may interpret as 

 the appearance in the field of an increasing number of free gran- 

 ules, and granular masses or plaques.* 



In addition to human colored blood-corpuscles, I have exam- 

 ined those of lower animals. Essentially the same intimate 

 structure as that which I have described exists in all. As exam- 

 ples, I will quote from my note-book a few words referring to 

 the examination of the colored blood-corpuscles of the ox and 

 the newt the one an example of the unnucleated, the other of 

 the nucleated corpuscles. 



* Max Schultze, who saw some of these granules and granular plaques in 

 healthy blood, prefers the designation " granule formation," as being non- 

 committal. Archiv fur Mikroskopische Anatomic, vol. 1, p. 38. 



