98 ORIGIN OF COLORED BLOOD-CORPUSCLES. 



The reason why the corpuscles of the smallest size do not 

 change in the solution of bichromate of potash of medium con- 

 centration, is, perhaps, that, being compact masses of living mat- 

 ter in which the haemoglobin is not as yet accumulated within 

 meshes, the solution does not reach and cannot extract the 

 hemoglobin. These small globules are probably intermediate 

 stages of development of colored blood-corpuscles, or the so-called 

 hematoblasts of Heitzmann * and of Hayem.t 



The Origin of Colored Blood-corpuscles. In 1872, J at a time 

 when I was ignorant of the structure and differences of bio- 

 plasson, according to its development, and consequently adhered 

 to the cell-theory, I made the following statements : 



Formation of Blood from Cartilage. In a horizontal section 

 of the condyle of a femur of a recently killed dog, several weeks 

 old, we .recognize, upon adding a drop of a one-half per cent, 

 solution of chloride of sodium, with moderate powers of the 

 microscope, two kinds of cartilage-corpuscles, first : large, pale 

 granular, distinctly nucleated cartilage-corpuscles; and second: 

 smaller shining, yellowish, indistinctly granular corpuscles^ 

 devoid of nuclei. There are transitions between these two kinds. 

 Still more marked is the difference in sagittal (antero-posterior) 

 sections of the cartilaginous epiphysis of the same dog. Near 

 the articular surface, the corpuscles, closely arranged, look 

 uniform ; but the nearer we come to the diaphysis, the more 

 marked is the difference between the pale and the yellow, shining 

 corpuscles. The glistening substance is often found in a crescent 

 shape around the pale granular, or it occupies the center of the 

 latter in the shape of a globular or irregularly angular body. 



Close to the border of the calcined basis-substance, the 

 difference between the two kinds of cartilage-corpuscles is very 

 marked. In a cavity of the basis-substance we often find the 

 shining, coarsely granular substance characterized by thorny 

 offshoots, and surrounded by a pale, granular zone, between 

 which and the basis-substance there is an apparently structure- 

 less rim. Solution of chloride of gold renders the finely granular 

 bodies pale violet, whereas the coarsely granular ones assume a 

 dark violet color, retaining their luster. 



" Studien am Knochen undKnorpel." Med. Jahrbiicher, 1872. 



t "Sur revolution des Globules rouges dans le Sang des Vertebres." 

 Compt. rend. Acad. des Sci., Nov. 12, 1877; Idem. Soc. de Biologie, Nov. 

 24, 1877. "Sur revolution des Globules rouges dans le Sang des Animaux 

 supe"rieurs." Compt. rend. Acad. des Sci., Dec. 31, 1877. 



t " Studien am Knochen und Knorpel." Medic. Jahrbiicher, Wien, 1872. 



