CONNECTIVE TISSUE. 243 



and a distinct yellow color. This indicates a new formation of 

 living matter. In 1872, I named these solid lumps "haemato- 

 blastic" (see page 98), as I had observed the new formation of 

 red blood-corpuscles arising from them. In 1873, I proved this 

 condition to be the juvenile state of living matter in general 

 (see page 51). 



H. Miiller asserted that many of the medullary corpuscles are 

 the productions of the original cartilage corpuscles, and in this 

 he was quite correct. But later observers, their number unfort- 

 unately being great, have disposed of the cartilage corpuscles by 

 saying that they fade and perish, and that all medullary cor- 

 puscles are " leukocytes" colorless blood-corpuscles, which have 

 migrated from the blood-vessels of the medullary spaces, or of the 

 perichondrium, through the cartilage and into the medullary 

 spaces. There is no ground whatever for such assertions. To 

 assume that leukocytes migrate through newly formed blood- 

 vessels, which are not yet in connection even with the old vascu- 

 lar system, sounds whimsical enough. Further to insist, however, 

 that leukocytes creep through the dense and unyielding basis- 

 substance (for, at that time, nothing was known of " juice- 

 canals' 7 ), is simply an absurdity. These hypotheses fall to the 

 ground when we know that the basis-substance contains a large 

 amount of living matter ; that a liquefaction only of this basis- 

 substance is required to free the bioplasson, from which, by its 

 rapid growth and by the splitting of its lumps, new medullary 

 corpuscles arise. The process, in short, is : re-appearance, division, 

 and new formation of bioplasson. 



That really the whole medullary tissue, filling the space 

 inclosed by a calcified frame, is a production of both the car- 

 tilage corpuscles and the living matter in the surrounding 

 basis- substance, is best illustrated by specimens where, with- 

 out a preliminary deposition of lime-salts, the territories of 

 cartilage tissue are immediately followed by medullary spaces. 

 (See Fig. 98.) 



Here we see, in certain territories of the cartilage, masses of 

 medullary corpuscles in no way connected with the medullary 

 spaces below. The spaces are exactly in a line with the terri- 

 tories directly above, and are filled with bioplasson lumps in all 

 stages of development. (See page 46.) The centers of the masses 

 exhibit a new formation, also, of red blood-corpuscles and blood- 

 vessels. 



(c) Formation of Red Blood-corpuscles and Blood-vessels. 



