246 



CONNECTIVE TISSUE. 



their non-calcified basis-substance. In the corresponding epi- 

 physeal cartilage of a pup of five days there was no deposition of 

 lime-salts present ; while the same cartilage of a pup six weeks 

 old contained a central semi-lunar calcareous nucleus, with its 

 concavity directed toward the diaphysis, the trabecula? of which 

 inclosed a number of medullary spaces. The significance of this 



calcareous deposition was 

 already known to Heinr. 

 Muller. 



Within the calcified 

 portions of the cartilage 

 metamorphoses occur in 

 the medullary spaces, 

 which, with a simulta- 

 neous solution of the 

 calcareous frame, lead 

 to the transformation of 

 the cartilage corpuscles 

 into blood-corpuscles and 

 blood-vessels, as well as 

 into medullary elements. 

 (See Fig. 99.) 



The process is the same 

 in advancing development 

 of bone-tissue at the bor- 

 ders of the diaphyseal or 

 intermediate cartilage, at 

 the border between the 

 epiphysis and the articular 

 cartilage, and at the bor- 

 der between the cartilagi- 

 naus and the bony plate of 

 the scapula. The central 

 yellow and shining portion 

 of the cartilage corpuscle 

 is transformed into a vesi- 

 cle, usually club-shaped, 

 containing red blood-cor- 

 puscles. The swelled blunt 

 extremity of the club is directed toward the periphery, while 

 the more solid pointed end lies toward the larger central medul- 



FIG. 100. FROM THE CARTILAGINOUS BOR- 

 DER OF THE SCAPULA OF A KITTEN. 

 FRESH SPECIMEN. [PUBLISHED IN 1873.] 



C, yellow, bright, vacuoled cartilage corpuscles ; 

 B, closed cartilage cavity, containing red blood-cor- 

 puscles ; M, club-shaped spaces, holding red blood- 

 corpuscles and haematoblasts. Magnified 800 diams. 



