356 INFLAMMATION. 



most of the inflammatory corpuscles remain united by delicate spoke-like off- 

 shoots, giving rise eventually to a new formation of tissue, consequently he 

 considered the inflammatory corpuscles and the pus-corpuscles to be one and 

 the same thing, and inflammation and suppuration as identical processes. 



In 1872,* when I took up the study of inflammation, in Strieker's labora- 

 tory in Vienna, I adhered to the cell theory, and my explanations of the phe- 

 nomena of inflammation were in accordance with this theory. One year later, 

 however, I announced new discoveries concerning the structure of " proto- 

 plasm " and the basis-substance, and also concerning the intimate nature of 

 the inflammatory process. t The articles in this chapter on inflammation of 

 the connective tissue are translations of my papers which were published in 

 1872 and 1873 the former being modified in accordance with the bioplas- 

 son views, the observed facts, however, and their description remaining unal- 

 tered. Instead of " protoplasm" I shall use the term "bioplasson." The 

 inflammation of the myxomatous variety of connective tissue is not dwelt 

 upon in the following articles. I refer to the article " Pulpitis," by Boedecker. 



1. INFLAMMATION OF CONNECTIVE TISSUE. 



(A) Inflammation of the Periosteum. On artificially producing 

 inflammation in the bone of a mammal, my experiments were 

 made on dogs, cats, and rabbits, inflammation in the perios- 

 teum, in the neighborhood of the injured part, was also induced, 

 as a rule. The appearances are identical, whether the inflamma- 

 tion occurs in the calcified or in the non-calcified, the fibrous or 

 the ribboned periosteum. A specimen furnished by the perios- 

 teum of the scapula of a grown cat, on the third day of inflam- 

 mation, after having been preserved in a solution of chromic 

 acid, represented the features seen in Fig. 149. 



We notice that, instead of the fibrous and ribboned structure 

 of the periosteum, a number of partly globular, partly fusiform, 

 elements are present, which are mostly nucleated, and grouped 

 in rhomboidal fields. 



An analysis of the elements gives the following result : some 

 of them contain a central lump of a bright yellowish color, either 

 homogeneous or pierced by vacuoles, and around it a pale, finely 

 granular zone. Other elements are found besides the homogeneous 

 lump ; these have but one pale nucleus, of varying size and glob- 

 ular shape. In a vesicular nucleus of this kind we notice some- 

 times one larger and sometimes several smaller iiucleoli. Lastly, 



* Studien am Knochen u Knorpel. Wiener Mediz. Jahrb., 1872. Ueber dieRiick-u Neubil- 

 dung von Blutgelassen im Knochen u. Knorpel. Wiener Mediz. Jahrb., 1873. 



t " Untersuchungen iiber das Protoplasma. v. Die Entziindung der Beinha-ut, dcs 

 Knochensund des Knorpels." Sitzuugsber. d. Wiener Akad. d. Wissensch., Juli. 1878. 



