INFLAMMATION. 359 



numerous globular elements, which are especially crowded in the 

 vicinity of the blood-vessels. In the parts situated between the 

 blood-vessels groups of elements or single corpuscles are found, 

 surrounded by a zone of basis-substance, which in the chromic 

 acid specimen has a homogeneous appearance, and bears a close 

 resemblance to normal medullary tissue. Groups of inflamma- 

 tory corpuscles give rise to a cartilaginous tissue. This fact can 

 be ascertained by observation of the forming callus in the later 

 days of the inflammation. 



In the cartilaginous callus, which is the offspring of the 

 inflamed periosteum, we sometimes see in a basis-substance, which 

 is usually striated, large, pale, nucleated bioplasson bodies. Fre- 

 quently we find smaller, yellowish, shining lumps, perforated 

 with vacuoles, and sometimes lumps composed of such yellow 

 granules. Finally, small cavities are observed in the basis-sub- 

 stance, which contain but one small bright-yellowish lump. (For 

 illustrations, see article on " Healing Process of Fractured 

 Bones.") 



The structure of this callus-tissue is in every particular iden- 

 tical with that of normal cartilage. The only difference is that 

 in the callus all corpuscles and their nuclei contain, at the points 

 of intersection of the reticulum of living matter, very shining, 

 yellowish granules, either single or in groups. These bodies 

 evidently represent the juvenile condition of the bioplasson. The 

 newly formed cartilage tissue is traversed by straight, glistening 

 fibers, which divide the tissue into rhomboid al fields of varying 

 size. These elastic fibers belonged originally to the periosteal 

 tissue, and remained unaltered by the inflammatory process. 

 They are recognized as such even in calcified portions of the 

 cartilage j they, without any apparent regularity, traverse both 

 the calcified basis-substance and the newly formed medullary 

 spaces. That the process of inflammation in periosteum can 

 produce not only medullary corpuscles and cartilage tissue, but 

 red blood-corpuscles also, I propose to demonstrate in the next 

 articles. 



Since having made the above observations, I have seen exactly the same 

 changes in the inflammation of fibrous connective tissue in the derma of the 

 skin, the pericementum of the tooth, and in many other localities (see 

 corresponding articles). The process was materially the same. First a dis- 

 solution of the basis-substance took place, which led to a freeing and re- 

 appearance of the bioplasson, previously concealed in the basis-substance. 

 Next by an outgrowth of single granules of bioplasson new elements arose, 



