INFLAMMATION. 363 



had either assumed a spindle shape or were fused into nucleated 

 bioplasson masses, with a simultaneous production of blood- 

 corpuscles and blood-vessels in the middle of the medullary space. 

 Close to the border of these spaces the corpuscles exhibited no 

 other changes than those above described. The epiphyseal bone, 

 by dissolution of its basis-substance and increase of the corpus- 

 cles, also appeared to be provided with medullary spaces, and 

 the perforation made by the iron was, after several days' inflam- 

 mation, filled with nucleated masses and fusiform elements. 



These experiments prove that a simultaneous injury of the 

 cartilage and the bone is followed by a calcification of the car- 

 tilage along the border of the wound, and afterward by a dis- 

 solution of the calcified basis-substance, commencing in the 

 vicinity of the bone and advancing toward the articular surface. 

 The freed bioplasson behaves in a manner similar to that of 

 inflamed bone. 



Injuries at the Lateral Portions of the Articular Cartilage. 

 The nearer the lateral edge of the articular cartilage the hot 

 iron was applied, the more intense were the changes in the endo- 

 thelium, in the synovial membrane, in the fibrous cartilage, and 

 in the neighboring periosteum arid tendons. 



At the edge of the condyle of a young cat, on the second day 

 after the injury, the tissues covering the cartilage were thick- 

 ened and rendered cloudy by a considerable infiltration with 

 inflammatory corpuscles. The tissue of the synovial membrane 

 and the periosteum exhibited groups of corpuscles, which in 

 some places were so crowded that only slight remnants of the 

 fibrous bundles were visible. 



In specimens of a young rabbit, from the sixth day of inflam- 

 mation, the surface of the cartilage was covered with a contin- 

 uous, freely nucleated layer of bioplasson, which was not sharply 

 marked from the subjacent cartilage tissue. The cavity of the 

 wound of the cartilage was found to contain along its borders 

 numerous tracts of corpuscles, closely packed together, and 

 uniting with analogous tracts proceeding from the subjacent 

 bone. (See Fig. 153.) 



Upon examining hyaline cartilage at points where it passed 

 into the fibrous variety, and into periosteum, I recognized large 

 cavities filled with corpuscles, containing large nuclei, often so 

 closely arranged that the boundaries between the corpuscles 

 could not be distinguished. Similar formations were found also 

 at the border of the scapula of a young dog, on the fifth day 



