

INFLAMMATION. 373 



above, lead to formations, constantly met with in the immediate 

 vicinity of the inflammatory district. A number of newly 

 formed medullary spaces are filled with yellowish, shining ele- 

 ments, which, in their form and the nature of the basis-substance 

 surrounding them, are analogous to normal juvenile medullary 

 corpuscles. In such spaces a more or less abundant new forma- 

 tion of red blood-corpuscles, and also, though not constantly, of 

 blood-vessels, is going on ; the spaces, as a rule, contain in their 

 centers blood-corpuscles and blood-vessels, and at their periphery 

 bioplasson bodies of varying size. Sometimes red blood-cor- 

 puscles originate in multinuclear bioplasson masses, as I de- 

 scribed in 1872. 



Finally, I emphasize that the living connection of the bioplasson 

 bodies, except the hcematoblasts, is not interrupted in the non-puru- 

 lent inflammation of bone. An isolation can be asserted to exist only 

 in colored blood-corpuscles and in pus-corpuscles. The blood-cor- 

 puscles float in a liquid whose origin is connected with a partial 

 paling and waste of bioplasson. The formation of this liquid 

 always occurs within the first vacuoles i. e., the first vascular 

 tubes, and both the liquid and the newly formed red blood-cor- 

 puscles take part in the circulation as soon as the newly formed 

 vessels join the older ones. It has been proved by Bustizky * that 

 from the freed bioplasson in the process of inflammation of bone, 

 pus-corpuscles also originate. 



New Formation of Blood-vessels in Inflamed Bone-tissued In 

 bone in which inflammation is artificially induced, a very active 

 new formation of blood-vessels takes place.f These are mostly 

 capillaries arising from the elements of the decalcified, but not 

 dissolved, bone-tissue, and in medullary spaces originating from 

 the derivations of the bone-tissue viz., the medullary corpuscles. 



* " Untersuchungen iiber Knocheneiterung." Wiener Mediz. Jahrbiicher, 

 1871. 



t "Ueber die Ruck- u. Neubildung von Blutgefassen im Knocheii u. 

 Knorpel." Wiener Mediz. Jahrbiicher, 1873. 



t R. Volkmann (Langenbeck's Archiv f. Klinische Chirurgie, IV. Bd. 

 1863) describes a new formation of vascular canals in the compact substance 

 of bone, occurring in so-called " vascular ostitis." What this author describes 

 is not identical with what I have seen, for he maintains that in the formation 

 of vascular canals the bone-corpuscles take only an accidental part, or do not 

 participate in the least. How the vessels themselves are formed he does not say. 



H. Lessen (Virchow's Archiv, Bd. lv v 1872) attempts to demonstrate, in 

 specimens obtained from dry bone, that the canalization of bone-tissue 

 really starts from bone-corpuscles. 





