376 INFLAMMATION. 



bioplasson tracts were seen, which, by vacuolation, became hol- 

 lowed, often exhibiting transverse septa, the remnants of the 

 walls of the vacuoles, and containing haRmatoblasts. From the 

 walls of these forming blood-vessels, solid buds or fusiform or 

 club-shaped prolongations arose, which indicated the formation 

 of new, collateral branches of blood-vessels. Not all the red 

 blood-corpuscles found in medullary spaces were inclosed in 

 blood-vessels, for I often met with blood-corpuscles, isolated or in 

 groups, among the medullary elements which had sprung from 

 inflamed bone-tissue, without a trace of an investing bioplasson 

 layer. Such corpuscles evidently are never carried into the circu- 

 lation, and I was unable to discover either their office or destiny. 



Often, multinuclear bioplasson masses were found, holding in 

 their substance a varying number of red blood-corpuscles. Sev- 

 eral times I observed an outer investment of spindle-shaped bod- 

 ies, which surrounded the multinuclear masses. Sometimes the 

 spindle-shaped bodies produced a well-marked, broad layer 

 around these masses, which had been partly changed into a homo- 

 geneous or finely granular, possibly liquid, substance. Along 

 the investing layer, inside the caliber, wreaths of haematoblasts 

 were seen. All these features indicated the formation of veins , 

 but I was not able to determine that the investing spindles were 

 muscle formations. 



That in inflamed tissues a new formation of arteries occurs I 

 am certain from a specimen of Prof. Strieker's, who, in 1871, 

 showed me an inflamed cornea I cannot recall whether of a 

 frog or a rabbit in which a newly formed artery could be posi- 

 tively diagnosticated. 



Conclusions arrived at in 1873. Inflammation was considered 

 by humoral pathologists to consist essentially in a diseased con- 

 dition of the blood and an exudation of its plasma ; while cell- 

 ular pathologists located the disease predominantly in the 

 " individuals," the "tissue-cells." The latter view, announced 

 by Virchow, was the leading one up to our time. 



The presence of an exudation, the altered liquid of the blood, 

 in the inflammatory process, needs to-day no special proof. It 

 has never been doubted. The phenomena in the inflammation 

 of bone could not be explained without the presence of a liquid 

 which causes a dissolution first of the lime-salts and afterward of 

 the glue-yielding basis-substance. Inflamed cartilage tissue like- 

 wise furnishes important proofs of the presence of an exudation. 

 The fact that injuries entirely confined to hyaline cartilage pro- 



